Enhancement of Resilience of the UTHSC RBL Facility, Biosafety and Countermeasure Discovery

项目摘要 田纳西大学健康科学中心（UTHSC）区域生物防护实验室（RBL） 位于孟菲斯市中心的校园内，在医疗区的心脏。医疗区包括 圣裘德儿童医院、地区一健康医院、孟菲斯退伍军人医疗中心和Le Bonheur 儿童医院UTHSC RBL的首要使命是在以下方面提供领导和支持： 发现和开发新的药物、疫苗和诊断方法，以保护广大民众 传染病和生物恐怖主义的威胁RBL支持和促进基本的 研究和转化研究，导致生物防御对策的发展， 新出现的传染源除了上述区域实体外，我们还支持学术研究， 政府和商业实体，国内和国际。联合国的长期目标和宗旨 UC 7提案侧重于创建三个核心，以支持RBL管理和运营，并增强 促进生物防御、新发传染病和大流行病的医学对策研究 RBL的准备和响应。运作和使用的总体目标和战略计划 RBL和设施核心（目标1）、BSL-3实践核心（目标2）和生物防护 研究支援服务核心（目标3）。目的1.提供设施管理、维护 和操作核心，将整合机械和饲养场基础设施的预防性维护， BSL-3和ABSL-3防护所需的科学/生物安全设备。目标2.提供BSL- 3个实践核心，将整合BSL-3病原体的业务管理和培训， 有些是精选代理，促进沟通，协调合规性、安全性、个人能力， 和实践在我们的RBL员工和我们的用户。目标3.为了促进和推动研究， 生物防护研究支持服务（S）的核心伞下的“抗病毒和 抗微生物对策发现和开发核心“（本文缩写为A2 CD 2C）。的 A2 CD 2C在RBL网络中是独一无二的，专注于为受感染的治疗动物提供LCMS/MS研究 组织中的BSL-3和提供药物药效学。操作和使用的战略使命 RBL和三个核心是提供一个无缝和集成的管理和运营结构， 有效地为客户和用户提供适当的设施控制，生物安全和选择代理 合规我们在这方面的战略愿景是为RBL网络和科学提供领导 通过讲座和出版物分享最佳实践和发现。

Project Abstract The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) resides within the campus in downtown Memphis in the heart of the medical district. The medical district includes St. Jude Children’s Hospital, Regional One Health Hospital, Memphis VA Medical Center, and Le Bonheur Children’s Hospital. The overarching mission of the UTHSC RBL is to provide leadership and support in the discovery and development of new drugs, vaccines and diagnostics that would protect the general population from emerging and reemerging infectious diseases and bioterrorism. The RBL supports and fosters basic research and translational research that leads to the development of countermeasures for biodefense and emerging infectious agents. In addition to the regional entities above, we support research for academic, government and commercial entities, nationally and internationally. The long-range objectives and goals of the UC7 proposal focus on the creation of three Cores to support RBL management and operations, and enhance and facilitate medical countermeasure research for biodefense, emerging infectious diseases, and pandemic preparedness and response at the RBL. The overall objectives and strategic plan for the operation and use of the RBL and the Facilities Core (Objective 1), BSL-3 Practices Core (Objective 2) and the Biocontainment Research Support Service Core (Objective 3). Objective 1. To provide a Facility Management, Maintenance and Operation Core that will integrate preventive maintenance of mechanical and vivarium infrastructure and scientific / biosafety equipment necessary for BSL-3 and ABSL-3 containment. Objective 2. To provide a BSL- 3 Practices Core that will integrate the management of operations and training for BSL-3 pathogens of which some are select agents, promotes communication and harmonize compliance, security, individual competency, and practices across our RBL Staff and our Users. Objective 3. To facilitate and advance research within the Biocontainment Research Support Service(s) Core under the umbrella of the “Antiviral & Antimicrobial Countermeasures Discovery & Development Core’ (herein abbreviated as A2CD2C). The A2CD2C is unique within the RBL network in its focus on providing LCMS/MS studies for infected, treated animal tissues in BSL-3 and providing drug pharmacodynamics. The strategic mission for Operation and Use of the RBL and the three Cores is to provide a seamless and integrated management and operational structure that efficiently serves its clients and users with the appropriate facility controls, biosafety and select agent compliance. Our strategic vision in this regard is to provide leadership for the RBL network and scientific community and share best practices and discoveries through lectures and publications.