SERUM ORGANOCHLORINE COMPOUNDS AND BREAST CANCER ON LI

我们正在进行一项由国家癌症研究所资助的乳腺癌与环境和生活方式的病例对照研究 因素（CA-63021）在两个大型长岛医院作为联邦授权长岛乳腺癌研究项目的一部分。本研究的一个主要目的是评估乳腺癌风险与先前暴露于 某些有机氯化合物（OCC），包括滴滴涕及其代谢物等农药，以及多氯联苯（PCB）。通过结构化问卷调查和通过对从患者和对照组手术获得的脂肪组织样本进行化学分析来评估暴露。在 在提交赠款时，几乎大多数关于OCC与乳腺癌相关的流行病学文献都是基于脂肪组织。最近，一些重要的研究已经发表，这些研究扩展到血清 这是可取的和紧迫的。经IRB批准和所有患者的知情同意，我们获得了 血清样品沿着脂肪组织，并且已经积累了来自900个样品的最终研究目标（300个病例、300个良性乳腺对照和300个手术对照）的大约600个冷冻血清的存档血清库。 对照）。所有血清样本均在给药前采集。这项建议的目的如下： 1.分析存档血清样本中的相同OCC分析物（农药和PCB？S），现在在脂肪组织中测定。 2.研究个体受试者中脂肪和血清OCC水平之间的关系，以改善仅使用这些生物来源之一（通常为血清）的研究的解释。 3.探讨脂肪和血清OCC水平与其他乳腺癌危险因素（如年龄、体重指数、文化程度和居住地）的关系。 4. (a)估计与经其他风险因素校正的OCC血清水平相关的乳腺癌风险，（B）确定此类估计值是否与基于脂肪水平的估计值存在实质性差异，如果存在实质性差异，（c） 找出这种差异的原因。

We are carrying out an NCI-funded case control study of breast cancer in relation to environmental and lifestyle factors (CA-63021) in two large Long Island hospitals as part of the Federally mandated Long Island Breast Cancer Study Project. A major aim of this study is the evaluation of breast cancer risk in relation to prior exposure to certain organochlorine compounds (OCC), including pesticides such as DDT and its metabolites, as well as polychlorinated biphenyls (PCBs). Exposures are evaluated via a structured questionnaire and through chemical analysis of samples of adipose tissue obtained surgically from patients and controls. At the time the grant was submitted, nearly most epidemiological literature on OCC in relation to breast cancer was based on adipose tissue. Recently, several important studies have been published which make an extension to serum both desirable and urgent. With IRB approval and informed consent from all patients, we have obtained serum samples along with adipose tissue, and have accumulated an archived serum bank of approximately 600 frozen sera out of an eventual study goal of 900 samples (300 cases, 300 benign breast controls, and 300 surgical controls). All serum samples were collected prior to treatment. This proposal has the following aims: 1. To assay the archived serum samples for the same OCC analytes (pesticides and PCB?S) that are now assayed in adipose tissue. 2. To study the relationship between adipose and serum levels of OCC within individual subjects in order to improve the interpretation of studies which use only one (usually serum ) of these biological sources. 3. To study the relationship between adipose and serum levels of OCC and other breast cancer risk factors, such as age, body mass index, education, and residence. 4. (a) To estimate the risk of breast cancer in relation to serum levels of OCC adjusted for other risk factors, (b) to determine whether such estimates differ materially from those based on adipose levels, and if so (c) to determine reasons for such differences.