MARIJUANA EFFECTS ON EQUILIBRIUM AND SIMULATED DRIVING

大麻是美国使用最广泛的非法药物。 它 损害平衡，经常在司机的血液中发现 卷入了车祸 虽然大麻对 平衡和驱动都分别进行了研究，一个关键的差距 在现有的知识大麻对驾驶的影响是缺乏一个 在同一组受试者中对这些影响进行严格检查。 拟议研究的具体目的是比较 安慰剂和两种效力的大麻对平衡和模拟 使用受试者内设计的汽车驾驶。 20成人付费 有驾驶经验的志愿大麻使用者将接受电池 在效力为0、1.77和3.95% delta-9 THC的六次测试中， 抽烟 测试将包括a）制动反应时间， 驾驶模拟器，B）驾驶中的冒险操作 模拟器，c）EquiTest平衡测量仪，d）临界闪烁 CNS活性的融合试验，e）感觉运动选择反应时间任务， 和f）通过视觉模拟量表测量的主观效果。 结果 将显示是否大麻剂量，损害驾驶也影响电机 平衡，反之亦然。 客观上看起来 增加“谨慎”驾驶可能同时恶化其他基本 驾驶方面，如平衡感。 不同的任务和 拟议研究的受试者内设计将澄清各种 大麻对司机的影响

Marijuana is the most widely used illicit drug in the United States. It impairs equilibrium and is often found in the bloodstream of drivers involved in automobile accidents. While the effects of marijuana on equilibrium and driving have both been studied separately, a critical gap in the existing knowledge of marijuana effects on driving is the lack of a rigorous examination of these effects within the same group of subjects. The specific aim of the proposed study is to compare the effects of placebo and two potencies of marijuana on equilibrium and simulated automobile driving using a within-subject design. Twenty adult paid volunteer marijuana users with driving experience will undergo a battery of six tests at potencies of 0, 1.77, and 3.95% delta-9 THC via smoked cigarettes. The tests will include a) brake reaction time within a driving simulator, b) risk-taking maneuvers within the driving simulator, c) the EquiTest balance measurer, d) the critical flicker fusion test of CNS activity, e) a sensorimotor choice reaction time task, and f) subjective effects as measured by visual analog scales. Results will show whether marijuana doses that impair driving also affect motor equilibrium and vice versa. Marijuana doses that objectively appear to increase "cautious" driving may simultaneously worsen other essential aspects of driving, such as sense of balance. The varied tasks and within-subject design of the proposed research will clarify the various effects marijuana has simultaneously within a driver.