HERBICIDE EXPOSURE EFFECT ON NATURAL KILLER CELLS

说明：在除草剂和杀虫剂中，2，4-D是最多的 常用的阔叶除草剂。许多研究表明， 农业工人患某些癌症的风险增加。而当 农民的癌症死亡率增加，总死亡率 农民比一般人口少。这一明显的悖论可能是 如果假设除草剂对 免疫系统的某些方面，但不是全部。这是一个假设 项目是2，4-D增加了免疫相关疾病的发病率 直接抑制NK细胞活性或通过改变 从1型(干扰素-γ)到2型分泌的细胞因子的分布 (IL-4)型。

DESCRIPTION: Among the herbicides and pesticides, 2,4-D is the most commonly used broadleaf herbicide. Many studies have demonstrated an increased risk of certain cancers among agricultural workers. While the mortality from cancer is increased among farmers, the overall mortality of farmers is less than the general population. This apparent paradox can be reconciled if one hypothesizes that herbicides have a selective effect on some, but not all, aspects of the immune system. The hypothesis of this project is that 2,4-D increases the incidence of immunologically related cancers by inhibiting NK cell activity either directly or by altering the profile of cytokines secreted from a type 1 (interferon-gamma) to a type 2 (IL-4) pattern.