Effect of Acamprosate on CNS hyperexcitability in alcoho

临床和临床前研究表明，酒精依赖的过程涉及高谷氨酸能状态，这被认为是情绪失调的信号，导致渴望和复发，以及导致酒精患者认知障碍和脑灰质损失的神经毒性。临床前数据表明，阿坎prosate可能是一种有效的药物，用于靶向反复发作的戒断期间出现的高谷氨酸能状态。该方案的主要目的是通过随机对照试验评估阿坎prosate对戒断期间和戒断后早期中心谷氨酸/谷氨酰胺浓度（由MR光谱测定）的影响。此外，正在获得探索性的生物学和临床措施进行二次分析。

Clinical as well as preclinical studies indicate that the process for developing alcohol dependence involves a hyperglutamatergic state, which is thought to be a signal for emotional deregulations leading to craving and relapse, as well as neurotoxicity leading to cognitive impairment and loss of brain grey matter in alcoholic patients. Preclinical data indicate that acamprosate might be a useful agent to target the hyperglutamatergic state that develops during recurring episodes of withdrawal The primary aim of the protocol is to evaluate, using a randomized controlled trial, the effects of acamprosate on central glutamate/glutamine concentrations (as determined by MR spectroscopy) during withdrawal and the early post withdrawal period. In addition, exploratory biological and clinical measures are being obtained for secondary analyses.