On the Hunt: Boosting Productivity of Cell Factories by Advanced Searches

该项目旨在促进我们对酵母（工业主力和模式生物）蛋白质分泌的分子机制的基本理解。它将开发一个独特的多方面的研究平台，以识别和分析在单细胞水平上具有所需性状的优质酵母菌株。预期结果包括用于高通量菌株分析的新分析工具和酵母分子生物学的先进知识，可用于改善下一代燃料，食品和药品的细胞工厂。这将通过促进生物技术产业的增长，促进向可持续社会的过渡，提高澳大利亚的生物安全，提供显著的经济和社会效益。

This project aims to advance our fundamental understanding of molecular mechanisms underlying protein secretion in yeast, an industrial workhorse and a model organism. It will develop a unique multifaceted research platform to identify and analyse superior yeast strains with the desired traits at the single-cell level. Expected outcomes include a new analytical tool for high-throughput strain analysis and advanced knowledge of yeast molecular biology that can be applied to improve cell factories for the next generation of fuels, food and pharmaceuticals. This will provide significant economic and social benefits by boosting biotech industry growth, facilitating the transition to a sustainable society and improving Australia’s biosecurity.