Hispanic Chronic Renal Insufficiency Cohort (CRIC) Study

描述（由申请人提供）： 根据2002年美国人口普查，拉美裔现在是美国最大的少数民族。西班牙裔终末期肾病（ESRD）人口也急剧增加，1996年至2001年期间，接受透析的西班牙裔人数增加了70%以上。考虑到西班牙裔总体人群的规模不断增加、糖尿病的高患病率以及西班牙裔ESRD的发病率增加，预计西班牙裔ESRD人群将进一步增长。尽管这个问题的严重性，很少有人知道西班牙裔慢性肾脏病（CKD）的早期阶段。伊利诺伊大学芝加哥分校（UIC）是慢性肾功能不全队列（CRIC）研究的七个临床中心之一，该研究是一项由NIH赞助的多中心研究，旨在调查3，000名CKD参与者中肾脏和心血管疾病（CVD）进展的风险因素。CRIC研究组群是50%的白色和50%的黑人。本申请旨在建立一个相当大的西班牙裔CKD患者队列，并将其纳入整体CRIC研究。本申请的总体目标是： 1.确定西班牙裔CKD患者肾脏疾病进展和亚临床CVD的预测因子。 2.比较西班牙裔CKD患者与非西班牙裔白人和黑人中肾脏疾病和亚临床CVD的进展率。 3.提高肾小球滤过率（GFR）预测方程在西班牙裔CKD患者中的准确性。 为了实现这些目标，我们将在UIC招募并保留316名患有CKD的西班牙裔受试者，以进行相关暴露（人口统计学、病史、药物、饮食、认知功能和生活质量）的年度访视，并测量亚临床CVD和肾功能。为了检验对西班牙裔美国人特别重要的假设，该提案将重点关注与内脏肥胖、炎症和医疗保健差异相关的问题。拟议的研究与CRIC研究的联系为探索西班牙裔CKD和CVD进展的风险因素和机制提供了前所未有的机会，这些问题从科学和公共卫生的角度来看都是至关重要的。

DESCRIPTION (provided by applicant): According to the 2002 U.S. Census, Hispanics are now the nation's largest minority group. There has also been a dramatic rise in the Hispanic end stage renal disease (ESRD) population, with the number of Hispanics on dialysis increasing by more than 70 percent between 1996 and 2001. Further growth of the Hispanic ESRD population is expected in view of the increasing size of the overall Hispanic population, a high prevalence of diabetes, and an increased incidence of ESRD in Hispanics. Despite the magnitude of this problem, little is known about earlier stages of chronic kidney disease (CKD) in Hispanics. The University of Illinois at Chicago (UIC) is one of seven clinical centers for the Chronic Renal Insufficiency Cohort (CRIC) Study, which is an NIH-sponsored multi-centered study investigating risk factors for progression of kidney and cardiovascular disease (CVD) in 3,000 participants with CKD. The CRIC Study cohort is 50 percent White and 50 percent Black. This application seeks to establish a sizable cohort of Hispanics with CKD that will be integrated into the overall CRIC Study. The overall aims of this application are: 1. To determine predictors of progression of kidney disease and subclinical CVD in Hispanics with CKD. 2. To compare rates of progression of kidney disease and subclinical CVD in Hispanics with CKD with those seen in non-Hispanic Whites and Blacks. 3. To improve the accuracy of glomerular filtration rate (GFR) prediction equations in Hispanics with CKD. To achieve these aims, we will recruit and retain 316 Hispanic participants with CKD at UIC to undergo annual visits for relevant exposures (demographics, medical history, medications, diet, cognitive function, and quality of life) and measurements of subclinical CVD and renal function. To test hypotheses of particular importance to Hispanics, this proposal will focus on issues related to visceral adiposity, inflammation, and health care disparities. The linkage of the proposed study to the CRIC Study provides an unprecedented opportunity to explore risk factors and mechanisms for CKD and CVD progression in Hispanics, which are problems of critical importance from both scientific and public health perspectives.