Molecular Microbial Persistance and Pathogenesis

21世纪的开始标志着人们认识到传染病的威胁越来越大 世界范围内微生物抗生素耐药性、微生物抗原性带来的严峻挑战 变异、遗传潜伏期和新出现的感染源。微生物进化出了一种令人困惑的 一系列持久性机制，避免主机防御导致已建立的感染，从而导致 疾病或死亡。为了解决这些复杂的问题，在分子水平上定义 微生物进化、持久性和致病机制的潜在机制，需要 跨学科和协作的研究努力。因此，我们在这里描述了大学范围内的跨学科 《分子微生物持久性与致病机理》(MMPP)博士前和博士后培训计划 博士后实习生结合了出色的培训资源和由高度 由匹兹堡大学医学院、匹兹堡大学研究生院30名教师导师组成的互动团队 公共卫生和文理学院。MMPP培训计划的基本原理是 让博士后和博士后实习生沉浸在分子科学的跨学科项目中 对各种病毒、细菌和原生动物的机制研究将提供最有效的基础 获得全面的专业知识和经验，为未来微生物持久性和 发病机制。MMPP培训计划旨在吸引最优秀和最聪明的学员，创造 与微生物持久性和研究相关的教学和研究培训的独特机会和环境 发病机制，加强不同大学单位之间的研究合作，并优化 研究和培训资源的利用。因此，MMPP培训计划的目标是生产 具有跨学科和独特视角的下一代独立调查人员 在分子水平上阐明微生物机制所需的协作研究培训 持久力和发病机制，并利用这些信息开发新的有效预防和 传染病的治疗策略。

The beginning of the 21stCentury is marked by a realization of the increasing threat of infectious diseases worldwide and the formidable challenges posed by microbial antibiotic resistance, microbial antigenic variation, genetic latency, and emerging infectious agents. Microorganisms have evolved a confounding array of persistence mechanisms to avoid host defenses leading to established infections that result in disease or death. To address these complex problems it is essential to define at the molecular level the mechanisms underlying microbial evolution, persistence, and pathogenesis, studies that require interdisciplinary and collaborative research efforts. Thus, we describe here a university-wide interdisciplinary training program in "Molecular Microbial Persistence and Pathogenesis" (MMPP) for predoctoral and postdoctoral trainees that combines outstanding training resources and opportunities provided by a highly interactive team of 30 faculty mentors in the University of Pittsburgh School of Medicine, Graduate School of Public Health, and Faculty of Arts and Sciences. The rationale for the MMPP Training Program is that the immersion of predoctoral and postdoctoral trainees into an interdisciplinary program of molecular mechanistic studies of diverse viruses, bacteria, and protozoa will provide the most effective foundation to gain comprehensive expertise and experience for future critical studies of microbial persistence and pathogenesis. The MMPP training Program is designed to attract the best and the brightest trainees, create unique opportunities and environment for didactic and research training relevant to microbial persistence and pathogenesis, to enhance research collaborations among different university units, and to optimize the utilization of research and training resources. Thus, the goal of the MMPP Training Program is to produce the next generation of independent investigators with unique perspective of interdisciplinary and collaborative research training required to elucidate at the molecular level the mechanisms of microbial persistence and pathogenesis and to use this information to develop new and effective prevention and treatment strategies for infectious diseases.