Assessment of Auditory Function in Patients with Parkinson Disease

描述（由申请人提供）： 帕金森病（PD）患者的听觉功能的研究很少进行或发表。少数研究的结果表明，PD患者的听觉缺陷（包括听力损失）的患病率和严重程度高于年龄相似的健康对照受试者。一些作者和临床医生建议对帕金森患者进行常规听觉功能评估，因为这种疾病的感觉表现通常没有正式评估，因此被误诊或诊断不足。未经治疗的听力损失或听觉处理缺陷可能会导致沟通问题，降低PD退伍军人的生活质量。这项研究将使用听觉功能的行为测试，听觉事件相关电位（AERPs）和问卷调查来提供帕金森患者听觉功能的详细评估。从这个试点项目的结果将提供必要的数据，设计一个全面的优点审查的建议，将包括在这个人群中的听觉缺陷的康复干预措施的评估。目的：这项研究计划的长期目标是识别帕金森病（PD）退伍军人，他们有与疾病相关的听觉缺陷的风险，以便解决当前的困难，并预防或治疗进一步恶化。本研究的目的是评估帕金森病（PD）患者的外周和中枢听觉功能。这项研究的中心假设是，帕金森病患者的听觉处理缺陷的发生率和严重程度高于年龄匹配的对照组。我们的假设是在支持性初步研究的基础上提出的。具体目标：我们将检验我们的中心假设，并通过追求以下具体目标来实现本申请的目的：具体目标1：评估PD患者的外周听力（听觉阈值），并将结果与年龄匹配的未患PD的对照受试者的结果进行比较。具体目标二：评估PD患者的中枢听觉处理，包括言语感知能力，并将结果与年龄匹配的未患PD的对照受试者的结果进行比较。研究设计：研究组将包括50名帕金森病患者和50名年龄和性别匹配的健康对照受试者。所有受试者将参加3次预约：1）初始评价和体格检查; 2）外周和中枢听觉测试; 3）电生理记录。每天服用左旋多巴的PD患者将在早晨接受研究程序，在服用药物后3小时内。影响：在这项研究的结论，我们将有一个更好的了解帕金森患者所经历的听觉问题和缺陷。这些信息可用于开发和评估干预措施，以改善经历此类缺陷的患者的听觉处理。最终，这些干预措施可能有助于减缓甚至逆转中枢听觉系统的功能退化。从拟议的研究和相关调查的数据将有助于患者的选择和结果评估这些和其他康复干预措施。最终，这些干预措施将有助于改善退伍军人和非退伍军人PD的生活质量。 公共卫生相关性： 患有帕金森病（PD）的退伍军人经历听觉缺陷（包括听力损失），其患病率和严重程度高于相似年龄的健康对照受试者。这项研究将使用听觉功能的行为测试，听觉事件相关电位（AERPs）和问卷调查来提供帕金森患者听觉功能的详细评估。在这项研究的结论，我们将有一个更好的了解这些患者所经历的听觉问题和缺陷。这些信息可用于开发和评估干预措施，以改善帕金森病患者的听觉处理。这些干预可能有助于减缓甚至逆转中枢听觉系统的功能退化。从拟议的研究和相关调查的数据将有助于患者的选择和结果评估这些和其他康复干预措施。最终，这些干预措施将有助于改善退伍军人和非退伍军人PD的生活质量。

DESCRIPTION (provided by applicant): Few investigations of auditory function in patients with Parkinson Disease (PD) have been conducted or published. Results from a small number of studies indicate that PD patients experience auditory deficits (including hearing loss) with greater prevalence and severity than healthy control subjects of similar age. Some authors and clinicians recommend that auditory function should be evaluated routinely in Parkinson patients because such sensory manifestations of the disease are often not formally assessed, and thus are misdiagnosed or under- diagnosed. Untreated hearing loss or auditory processing deficits can contribute to communication problems that reduce the quality of life for Veterans with PD. The proposed study will use behavioral tests of auditory function, auditory event-related potentials (AERPs) and questionnaires to provide detailed assessments of auditory function in Parkinson patients. Findings from this pilot project will provide data necessary for the design of a full-scale Merit Review proposal that will include assessment of rehabilitative interventions for auditory deficits in this population. Objective: The long-range goal of this research program is to identify Veterans with Parkinson Disease (PD) who are at risk for auditory deficits related to their disease so that current difficulties can be addressed and further deterioration can be prevented or treated. The objective of this proposal is to assess peripheral and central auditory functions i patients with Parkinson Disease (PD). The central hypothesis of the proposed research is that deficits in auditory processing occur with greater prevalence and severity in Parkinson patients than in age-matched control subjects. Our hypothesis has been formulated on the basis of supportive preliminary studies. Specific Aims: We will test our central hypothesis and accomplish the objective of this application by pursuing the following specific aims: Specific Aim 1: Evaluate the peripheral hearing (auditory thresholds) of PD patients and compare the results to those from age-matched control subjects who do not have PD. Specific Aim 2: Evaluate central auditory processing, including speech perception ability, of PD patients and compare the results to those from age-matched control subjects who do not have PD. Study Design: Study groups will include 50 patients with Parkinson Disease and 50 age- and gender-matched healthy control subjects. All subjects will attend 3 appointments: 1) Initial evaluations and physical exam; 2) Peripheral and Central auditory testing; 3) Electrophysiological recordings. PD patients who take levodopa daily will undergo study procedures in the morning, within 3 hours of ingesting the medication. Impact: At the conclusion of this study, we will have a better understanding of auditory problems and deficits experienced by Parkinson patients. This information could be used to develop and assess interventions to improve auditory processing in patients who experience such deficits. Ultimately, these interventions might help to slow or even reverse functional degradation within the central auditory system. Data from the proposed study and related investigations would facilitate patient selection and outcome assessments for these and other rehabilitative interventions. Ultimately, these interventions will contribute to improved quality of life for Veterans and non-Veterans with PD. PUBLIC HEALTH RELEVANCE: Veterans with Parkinson Disease (PD) experience auditory deficits (including hearing loss) with greater prevalence and severity than healthy control subjects of similar age. The proposed study will use behavioral tests of auditory function, auditory event-related potentials (AERPs) and questionnaires to provide detailed assessments of auditory function in Parkinson patients. At the conclusion of this study, we will have a better understanding of auditory problems and deficits experienced by these patients. This information could be used to develop and assess interventions to improve auditory processing in Parkinson patients who experience such deficits. These interventions might help to slow or even reverse functional degradation within the central auditory system. Data from the proposed study and related investigations would facilitate patient selection and outcome assessments for these and other rehabilitative interventions. Ultimately, these interventions will contribute to improved quality of life for Veterans and non-Veterans with PD.