SIMULATION OF ARTERIAL BLOOD FLOW DYNAMICS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们想研究血液的屈服应力行为。特别感兴趣的是由于屈服应力水平的血流动力学和动脉疾病进展的调制。血液是一种屈服应力流体。当它静止时，它是一种像凝胶一样的固体，当它被剪切时，它开始流动，表现得像卡森流体。血液流变学分析使我们能够描述几个生物过程，这些过程对于理解人类生理和疾病过程以及设计新的诊断和治疗程序至关重要。血液流变学将被表示为具有不同程度的Casson屈服应力的Casson流体，该Casson屈服应力指示各种生理条件。我们使用Navier-Stokes方程来模拟动脉血流动力学。将从研究和教学生物医学图像库获得待使用的人类受试者的颈动脉的三维CT扫描图像。在研究中使用的数学模型是非线性和过渡的性质，不适合解析解，和一个数值方法，有限体积法，实施。数值方法是计算密集型的;因此，模拟将在超级计算环境中进行。计算流体动力学软件工具，如在匹兹堡超级计算中心（PSC）提供的FLUENT和GAMBIT，将用于模拟和数据可视化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to investigate the yield stress behavior of blood. Particular interest is modulation of flow dynamics and arterial disease progressions due to yield stress levels. Blood is a yield stress fluid. It is a solid like gel when it is at rest and when it is sheared it starts to flow and behave like a Casson fluid. Blood rheology analysis allows us to describe several biological processes which are essential to understand human physiology and disease processes and also to design novel diagnostic and treatment procedures. Blood rheology will be represented as a Casson fluid with different degrees of Casson yield stress designating various physiological conditions. We use the Navier-Stokes equation to model arterial blood flow dynamics. The three-dimensional CT scan imagery of carotid arteries of a human subject to be used will be obtained from research and teaching biomedical image repository. The mathematical models to be used in the study are non-linear and transit in their nature and are not amenable to analytic solution, and a numerical method, finite volume method, is implemented. The numerical approach is computational intensive; as a result, the simulation will be conducted in supercomputing environment. Computational fluid dynamics software tools such us FLUENT and GAMBIT which are available at Pittsburgh Super Computing Center (PSC) will be used in simulation and visualization of data.