FEASIBILITY STUDY OF DETECTION OF CERVICAL DYSPLYSIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们正在使用定量光谱学(QS)在活体内检测宫颈异型增生。我们已经开发了定量光谱成像(QSI)系统来收集感兴趣部位的在体反射光谱和荧光光谱。从每个组织部位测量的散射、吸收和荧光被用来识别宫颈高度鳞状上皮内病变(HSIL)。我们已经证明，与使用我们上一代三峰光谱仪的传统阴道镜相比，定量光谱分析在宫颈癌诊断中具有更好的准确性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are using Quantitative Spectroscopy (QS) to detect dysplasia in the uterine cervix in vivo. We have developed the Quantitative Spectroscopy Imaging (QSI) system to collect reflectance and fluorescence spectra in vivo from the site of interest. Measured scattering, absorption, and fluorescence from each tissue site are used to identify high-grade squamous intraepithelial lesions (HSIL) in the cervix. We have demonstrated that quantitative spectroscopy has much better accuracy in comparison to traditional colposcopy for cervical cancer diagnosis using our previous generation tri-modal spectroscopy instrument.