Training Program in Quantitative Biology and Physiology

描述（由申请人提供）：本提案寻求未来五年的支持，以继续我们已建立的名为定量生物学和生理学（QBP）的培训计划。我们的使命是培养博士研究科学家，他们具有：(1)对分子生物学，细胞生物学和生理学基础原理的定量理解；(2)将现代和定量驱动的实验方法与生物学和生理学相结合的能力；(3)综合基于生物和生理系统的机械和结构建模技能的能力；(4)通过整合生物或生理系统或过程的多个尺度（分子-细胞-组织-器官）来评估涌现特性和行为的能力。我们更新的具体目标是：保持和加强主要来自生物医学工程的核心跨学科导师队伍，也包括生物，物理，化学，数学，机械工程，电气和计算机工程以及波士顿大学医学院的部门。提供包括定量分子生物学，细胞生物学和生理学在多个长度尺度严格训练的程序课程。提供实验室轮岗，确保接触到与生物学和生理学多个尺度问题相关的定量和系统/动力学研究技术。为研究生提供进行跨学科、定量、综合并与实验和/或临床数据相关的论文研究的机会。通过期刊俱乐部、年度QBP研讨会和每月晚宴等互动方式，加强QBP项目和社区的独特身份和影响力。BME部门继续吸引高素质的学员，他们组织起来创造了一个授权的身份。这些受训者还支持促进QBP计划主题的活动，以丰富整个机构。我们扩大了我们的培训导师池，提高了整个部门的质量，并根据经验和反馈修改了我们的管理方法。我们期待有机会在下一个赠款周期中继续保持这一势头。

DESCRIPTION (provided by applicant): This proposal seeks the next five years of support to continue our established training program entitled Quantitative Biology and Physiology (QBP). Our mission is to train PhD research scientists who have: (1) a quantitatively based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern and quantitatively driven experimental methods with biology and physiology; (3) the ability to synthesize mechanistically and structurally based modeling skills with biological and physiological systems; and (4) the capacity to assess emergent properties and behaviors via integration across multiple scales (molecular-cellular-tissue-organ) of a biological or physiological system or process. The specific objectives of our renewal are: To maintain and strengthen a core interdisciplinary faculty of mentors primarily from Biomedical Engineering, but also including Biology, Physics, Chemistry, Mathematics, Mechanical Engineering, Electrical & Computer Engineering and departments at the BU School of Medicine. To provide a program curriculum that includes rigorous training in quantitative molecular biology, cell biology, and physiology at multiple length scales. To provide laboratory rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at multiple scales of biology and physiology. To provide graduate trainees with the opportunity to conduct thesis research that is interdisciplinary, quantitative, integrativ, and linked to experimental and/or clinical data. To strengthen the unique identity and impact of the QBP program and community via interactive components, including a Journal Club, a yearly QBP Symposium, and Monthly Dinners. The BME department continues to attract high caliber trainees who have organized to create an empowering identity. These trainees also sustain activities that foster the themes of the QBP program so as to enrich the entire institution. We have expanded our training mentor pool, improved the quality of the department as a whole, and revised our administrative approach based on experience and feedback. We look forward to the opportunity to continue this momentum during the next grant cycle. PUBLIC HEALTH RELEVANCE: This proposal seeks another five years of support to continue and enhance our established predoctoral-student training program in Quantitative Biology and Physiology (QBP). The mission of the QBP Program is to train PhD research scientists who have: (1) a quantitatively based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the capacity to synthesize modern and quantitatively driven experimental methods with biology and physiology; (3) the ability to synthesize mechanistically and structurally based modeling skills with biological and physical systems; and (4) the capacity to assess emergent properties and behavior via integration across multiple levels (molecular-cellular-tissue-organ) of a biological or physiological system or process.