Training and Education Program

摘要 两个SUNY医学院（SUNY斯托尼布鲁克和SUNY Downstate）为代表性不足的少数族裔提供服务 癌症健康差异较大的社区正在与NCI指定的Cold癌症中心合作 Spring Harbor实验室评估GI癌症（结直肠癌和结肠癌）的生物学和遗传学差异 胰腺），这可能与在种族和少数民族中观察到的癌症发病率和结局的差异有关 （URM）。对于癌症研究计划，我们的目标是增加代表性不足的少数民族的代表性， 在收集生物标本和从这些生物标本产生的链接的高维组学数据集时， 生物标本在这项计划拨款中，我们计划开发一个并行运作的SUNY Downstate GI生物库， 送到纽约州立大学斯托尼布鲁克GI生物银行。我们正在规划发展 一个综合生物医学信息学平台，将生物标本与纵向临床数据联系起来， 从这些标本中产生的数据。规划程序的第一步是制定一个 包括哪些数据元素以及开发受控词汇表的共识。以便增强社区 在种族和少数民族人口的参与性研究，我们计划利用资源， 纽约州立大学下州布鲁克林健康差异中心（由摩罗萨利夫博士领导）在开发 在服务不足的社区开展社区教育和外联方案， 少数民族。生物标本的收集将由两个试点研究项目P1和P2驱动。在P1中， 我们建议比较URM结肠癌和非URM结肠癌的基因组和表观遗传学特征。 在P2中，我们建议测试采用创新的3-D方法来生长胰腺类器官的可行性 （微型胰腺）从祖细胞（在Tuveson博士的实验室在CSHL开发）从细针 在纽约州立大学的两个医学校区收集的人类胰腺癌的核心活检。我们计划比较 URM胰腺类器官与非URM类器官的基因组和表观基因组谱分析。为 培训和教育计划，我们致力于改善代表性不足的少数民族的参与 在生物医学研究和提高认识的健康差距之间建立癌症研究人员。 在这项规划拨款中，纽约州立大学的两个医学院将与CSHL合作， 癌症健康差异生物医学科学学者证书课程。该计划旨在 让博士生从事转化医学，特别是在癌症健康的差距，通过促进这些 学生了解与其领域相关的疾病的表现，进展和治疗， 论文研究这条赛道需要增加一个临床共同导师，以通常的学生基础科学顾问 团队谁将帮助指导学生的生物医学/临床研究，并沉浸在临床的学生 经验，词汇和临床研究的整体文化。

ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of biospecimens and linked high dimensional ‘omic datasets generated from these biospecimens. In this planning grant we plan to develop a SUNY Downstate GI Biobank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the biospecimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations,we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of biospecimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson’s laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.