Alabama Clinical Trials Unit

描述(由申请人提供)：阿拉巴马州和阿拉巴马大学伯明翰分校(UAB)是日益增长的艾滋病毒/艾滋病流行的核心，对最脆弱的人群造成了不成比例的困扰。25年来，亚拉巴马州伯明翰大学艾滋病研究中心(CFAR)一直站在艾滋病毒预防和治疗研究的前沿。七年前，UAB CFAR成立了阿拉巴马州临床试验单位(A-CTU)：UAB调查人员的合作伙伴关系，致力于在美国一个资源匮乏的地区进行高影响的艾滋病毒相关研究。A-CTU一直在进行由艾滋病毒疫苗试验网络(HVTN)赞助的临床研究，即杀微生物剂试验 CTU在一栋大楼内共享资源，已有900多名参与者参加了45项不同的临床试验。该应用程序提供了添加HIV预防试验网络(HPTN)的计划，以创建单一的临床研究站点(CRS)。这个单一、协调的CTU解决艾滋病毒临床研究的优先领域，并利用与患者/参与者社区建立的伙伴关系、NIAID和行业资助的临床试验经验以及与UAB CFAR调查人员的合作。 相关性：本申请寻求批准继续进行临床试验，以促进我们对艾滋病毒及相关疾病的治疗和预防的了解。阿拉巴马州临床试验单位计划为几个不同的NIH赞助的网络进行这些试验，包括在阿拉巴马大学伯明翰分校的HVTN、HPTN、MTN和ACTG。

DESCRIPTION (provided by applicant): Alabama and the University of Alabama Birmingham (UAB) are in the heart of a growing HIV/AIDS epidemic that disproportionately afflicts the most vulnerable populations The UAB Center for AIDS Research (CFAR) has been at the forefront of HIV prevention and therapeutic investigation for over 25 years. Seven years ago, the UAB CFAR formed the Alabama-Clinical Trials Unit (A-CTU): A partnership of UAB Investigators dedicated to conducting high-impact HIV-related studies in a resource poor region of the United States. The A-CTU has been conducting clinical studies sponsored by the HIV Vaccine Trials Network (HVTN), the Microbicide Trials Network (MTN), and the Adult Clinical Trials Group (ACTG) and shares resources In a single building The CTU has enrolled over 900 participants Into 45 separate clinical trials. This application provides plans to add the HIV Prevention Trials Network (HPTN) to create a single Clinical Research Site (CRS). This single, coordinated CTU addresses priority areas in HIV clinical research and utilizes established partnerships with the patient/participant community, experience In NIAID- and Industry-funded clinical trials, and collaborations with UAB CFAR investigators. RELEVANCE: This application seeks approval to continue conducting clinical trials to advance our understanding of the treatment and prevention of HIV and related diseases. The Alabama Clinical Trials Unit plans to conduct these trials for several different NIH-sponsored networks Including the HVTN, HPTN, MTN, and ACTG at a the University of Alabama at Birmingham.