Accelerometry-derived latent class analysis and cancer in the Women's Health Accelerometry Collaboration

摘要 癌症是美国女性死亡的第二大原因，估计有289，150人 癌症相关死亡和927，910个新的癌症病例预计将在2021年发生在女性中。考虑 在生命周期中，几乎40%的女性会在一生中的某个时候被诊断出患有癌症。 了解造成这一巨大公共卫生负担的易受影响的风险因素至关重要。 观察性研究表明，自我报告的身体活动与许多疾病的风险增加之间存在关联。 癌症的类型。然而，没有足够的证据表明，数量，强度，持续时间和类型， 减少癌症风险所需的体力活动，特别是老年妇女。久坐不动的行为可以提供一个 更可行的干预目标，特别是老年人。然而，对于久坐不动的人， 行为和癌症风险。我们的原始应用程序（#1 R 01 CA 227122）被资助组装加速度计- 评估身体活动和久坐行为（从2011-2014年收集）和癌症事件， 两项妇女队列研究的死亡人数：妇女健康研究和妇女健康倡议 客观身体活动与心血管健康研究。总之，这两个队列被协调 并组成了妇女健康加速测量合作组织。我们正在运用复杂的方法 确定哪些身体活动和久坐行为特征对降低癌症风险最重要 超过22，000名62岁及以上的女性。两个队列判定癌症的随访 正在取得成果。目前的申请将通过美国国立卫生研究院支持申请人 多样性的补充和重点应用潜在类分析加速度。具体来说，文学 将审查用于加速度测量的潜在类别分析或潜在类别轨迹建模的使用情况， 进行。利用从审查中获得的知识，将在 来自妇女健康加速测量协作组的队列，用于身体活动和久坐行为。 然后，这些类将用于探索潜在类与整体和特定站点的关联 (e.g.,乳腺癌、肺癌）偶发性和致命性癌症。本项目将寻求解决某些模式的 体力活动和久坐不动的行为使妇女患癌症的风险较高或较低。 确定身体活动和久坐行为的新的癌症保护模式将有助于了解 身体活动和久坐行为指南，可用于干预， 降低风险。

Abstract Cancer is the second leading cause of death in the United States for women, with an estimated 289,150 cancer-related deaths and 927,910 new cancer cases predicted to occur among women in 2021. Considering the life span, almost 40% of women will be diagnosed with cancer at some point in their lifetime. Understanding amenable risk factors that contribute to this large public health burden is essential. Observational studies indicate associations between self-reported physical activity and increased risk of many types of cancer. However, there is insufficient evidence regarding the amount, intensity, duration, and types of physical activity required to reduce cancer risk, especially for older women. Sedentary behavior may provide a more feasible intervention target, especially for older adults. However, even less is known about sedentary behavior and cancer risk. Our original application (#1 R01CA227122) was funded to assemble accelerometry- assessed physical activity and sedentary behavior (collected from 2011-2014) and cancer incident events and deaths from two cohort studies of women: the Women’s Health Study and the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health Study. Together, these two cohorts were harmonized and comprise the Women’s Health Accelerometry Collaboration. We are applying sophisticated methods to determine which physical activity and sedentary behavior features are most important for reducing cancer risk among more than 22,000 women 62 years and older. Follow-up of both cohorts for adjudicated cancer outcomes is ongoing. This current application will support an applicant through a National Institutes of Health diversity supplement and focus on applying latent class analysis to accelerometry. Specifically, a literature review on the use of latent class analysis or latent class trajectory modelling applied to accelerometry will be conducted. Using the knowledge gained from the review, latent class measures will be derived among the cohort from the Women’s Health Accelerometry Collaboration for both physical activity and sedentary behavior. Those classes will then be used to explore the associations of the latent classes with overall and site-specific (e.g., breast, lung) incident and fatal cancer. This project will seek to address whether certain patterns of physical activity and sedentary behavior put women at higher or lower risk for incidence of cancer. Identification of new cancer-protective patterns of physical activity and sedentary behavior will help inform physical activity and sedentary behavior guidelines for cancer prevention and can be used in interventions to reduce risk.