Bioinformatics Support for Toxicogenomics Technologies

需要支持毒理基因组学分析的项目包括：1）支持循环无细胞DNA（ccfDNA）; 2）通过提供10种小鼠的树状图和SNP分析支持小鼠衰老研究; 3）支持体外细胞转化模型中砷相关变化的DNA甲基化的表观基因组学分析; 4）HepaRG的3D球状体分析。 使用倍数变化和p值进行来自TempO-Seq数据的差异基因表达; 5）为来自暴露于PFAS化合物的动物的胎盘和肝脏的微阵列毒理基因组学数据的分析提供支持; 6）为AFFF（水性成膜泡沫）的分析提供支持，以用于HTT测定中体外暴露后毒性的比较分析。

Projects needing support for toxicogenomic analysis included 1) support for circulating cell free DNA (ccfDNA); 2) support for Mouse Aging study by providing dendogram and SNP analysis for 10 strains of mice; 3) support epigenomic analysis of DNA methylation of arsenic-related changes in an in vitro model of cellular transformation; 4) analysis of 3D spheroids of HepaRG. Differential gene expression from TempO-Seq data was performed with fold chagnes and pvalues; 5) support was provided for analysis of microarray toxicogenomic data for placenta and liver from animals exposed to PFAS compounds; 6) support was provided for analysis of AFFF (aqueous film-forming foams) fpr comparative analysis of toxicity after in vitro exposures in HTT assays.