Center for Label-free Imaging and Multiscale Biophotonics (CLIMB)

摘要 无标签成像和多尺度生物光子学中心(SCRAPE)开发了尖端光学和 用于应对生物医学重大挑战的计算成像技术，包括癌症和 神经退行性疾病。建立在干涉测量、非线性、化学和化学的最新进展基础上 UIUC的计算成像，攀登将为尖端技术和培训中心建立一个独特的中心 生物光子学。具体地说，三个技术研发(TRD)项目将协同 BopPart小组在多模式和非线性成像方面的专业知识，来自 Anastasio组和Popescu组的定量相位成像，将新技术从 实验室到诊所和医疗点设置。在攀登开发的技术的统一概念是 使用本征对比成像从样本中提取定量生物标记物的能力，即无标记。这些 技术将首次推向手持式配置，以实现体内和护理点(POC) 手术。 我们制定了严格和包容的技术培训和传播计划，以及全面的 为下一代生物光子学研究人员在无标签领域出类拔萃做好准备的教育计划 成像。

SUMMARY The Center for Label-free Imaging and Multiscale Biophotonics (CLIMB) develops cutting-edge optical and computational imaging technologies for addressing grand challenges in biomedicine, including cancer and neurodegenerative diseases. Building upon the recent advances in interferometric, nonlinear, chemical, and computational imaging at UIUC, CLIMB will establish a unique technology and training hub for cutting-edge biophotonics. Specifically, the three Technology Research and Development (TRD) projects will synergize expertise in multimodal and nonlinear imaging from the Boppart group, computational imaging from the Anastasio group, and quantitative phase imaging, from the Popescu group, to translate new technology from lab-to-clinic and point-of-care settings. The unifying concept for the technologies developed at CLIMB is the ability to extract quantitative biomarkers from specimens using intrinsic contrast imaging, i.e., label-free. These technologies will be pushed for the first time to handheld configurations to allow in-vivo and point-of-care (POC) operation. We developed a rigorous and inclusive technology training and dissemination plan, as well as a comprehensive educational program to prepare the next generation of biophotonics researchers for excelling in label-free imaging.