Core C: Biostatistics, Bioinformatics, and Patient Registry Core

项目总结/摘要 生物统计学、生物信息学和患者注册中心提供统计学和生物信息学协作 为每个SPORE项目、发展研究和职业生涯提供数据管理支持 增强项目，以及其他核心。其成员具有乳腺癌内容知识。他们的 协作努力包括制定统计设计和分析计划，质量控制， 数据库开发、数据格式开发和处理、数据收集/提取和输入、数据 分析和解释，手稿准备和数据存档。生物统计学核心的存在 为SPORE调查人员提供了统计专业知识，包括最先进的数据分析 和数据管理资源，并提供一致和兼容数据的机制 装卸.通过这些努力，在上一个供资期间出版了59份出版物。 在此更新申请中，生物统计学、生物信息学和患者登记核心（核心C）已经发挥作用 与每个SPORE项目研究团队一起准备项目研究计划。在整个 开展本研究时，核心成员和小型研究者将参加项目团队会议 召开会议，以确保每位SPORE研究者在研究期间能够持续获得所需的统计专业知识。 他们的研究奋进的演变。通过这些合作活动，SPORE调查人员可以访问 一个具有乳腺癌内容知识的统计/生物信息学合作者团队，以确保 开发一种研究设计，可以生成数据来解决提出的问题，并确保 适用于复杂数据的统计和生物信息学分析技术的应用 在这些不同的项目中。这一核心补充和协助生物标本的工作， 病理学核心通过提供最先进的数据管理和与生物标本登记处的合作。 总之，核心C将有助于确保在马约诊所乳腺癌孢子的研究是在 一种有效率的、有效的、严格的方式。

Project Summary/Abstract The Biostatistics, Bioinformatics, and Patient Registry Core provides statistical and bioinformatics collaboration and data management support for each of the SPORE projects, Developmental Research and Career Enhancement projects, and the other cores. Its members have breast cancer content knowledge. Their collaborative efforts are included the development of a statistical design and analysis plan, quality control, database development, data form development and processing, data collection/abstraction and entry, data analysis and interpretation, manuscript preparation, and data archiving. The existence of the Biostatistics Core has provided SPORE investigators access to statistical expertise which includes state of the art data analysis and data management resources as well as provides a mechanism of consistent and compatible data handling. These efforts have resulted in 59 publications over the previous funding period. In this renewal application, the Biostatistics, Bioinformatics, and Patient Registry Core (Core C) has worked with each of the SPORE project research teams in preparing their project research plans. Throughout the conduct of this research, Core members will attend Project team meeting as well as smaller investigators meetings to assure each SPORE investigator has ongoing access to the statistical expertise needed during the evolution of their research endeavor. Through these collaborative activities, SPORE investigators have access to a team of statistical/bioinformatics collaborators with breast cancer content knowledge to ensure the development of a study design that can generate data to address the questions posed as well as to ensure the application of statistical and bioinformatics analysis techniques which are appropriate for the complex data generated in these diverse projects. This core complements and assists the efforts of the Biospecimen and Pathology Core by providing state of the art data management and collaboration with biospecimen registries. In summary, Core C will help assure that research in the Mayo Clinic Breast Cancer SPORE is carried out in an efficient, effective, and rigorous manner.