Neuropathogenesis of varicella zoster virus infection

水痘带状疱疹病毒（VZV）是一种引起水痘和带状疱疹的疱疹病毒。带状疱疹影响许多老年人，主要并发症是长期的剧烈疼痛或带状疱疹后神经痛，通常需要数月至数年的后续医疗护理。尽管它对社区有影响，但人们对这种病毒如何发挥作用和引起疾病知之甚少。我们的目标是提高我们对VZV如何感染神经细胞的理解，为开发新的治疗方法提供新的信息。

Varicella zoster virus (VZV) is a herpesvirus which causes chicken pox and shingles. Shingles affects many elderly people and a major complication is prolonged severe pain or post-herpetic neuralgia, often needing follow-up medical care for months to years. Despite its impact on the community, little is known about how this virus functions and causes disease. We aim to improve our understanding of how VZV infects nerve cells to provide new information for the development of new treatments.