Neuropathic pain drugs based on the endogenous opioid peptide Endomorphin 1.

我们开发了一种基于天然镇痛阿片肽的新型止痛药，内啡肽1。这种新药对动物神经性疼痛的作用类似于吗啡和加巴喷丁，但似乎是通过不同的机制起作用。我们将通过评估其副作用和动物耐受性诱导特性来完成对该化合物的临床前研究。我们还将继续开发这种重要肽的口服活性类似物。

We have developed a new pain drug based on the natural pain killing opioid peptide, Endomorhin 1. The new drug exhibits activity similar to morphine and gabapentin against neuropathic pain in animals but seems to act through a different mechanism. We will complete our preclinical investigation of this compound by assessing its side effect profile and tolerence inducing properties in animals. We will also continue our development of an orally active analogue of this important peptide.