Aberrations of eyes in normal and clinical populations

长期目标是实现新的，非侵入性的方法，用于量化眼睛的光学质量。 视网膜图像的波前像差测量与视网膜图像质量的关系 和视觉表现。 这一竞争性更新的具体目标是： 1.测试我们新的视网膜图像质量指标检测光学疾病变化的能力。 2.直接测试视网膜图像质量的变化可以预测未来视力的组织假设 视力丧失。 3.提高新开发的单值波像差度量的能力，以预测 通过增加前向散射的测量来实现视觉性能。 4.使用物理和计算机模型来测试我们的新分析的测量假设， 前向散射和探索方法，以提高我们的分析速度，效率和准确性。 这些具体目标将通过以下方式实现： 1.对120例白内障患者进行5年纵向研究，监测视力和视网膜功能 使用从Shack/Hartmann波前传感导出像差和散射度量的图像质量。 2.分析数据以测试我们的指标是否可以检测到短时间内的变化， 预测未来的损失，并在此过程中不断改进我们的指标。 3.将波像差和前向散射建立到物理和计算机模型中进行测试 测量假设并探索改进我们分析的方法。 这一系列的研究将促进对视网膜图像质量及其与视网膜病变的关系的基本理解。 视觉性能，并提供一种用于评估眼睛光学质量的灵敏方法， 监测治疗旨在改善眼睛的光学质量。

The long-term goals are to reify new, non-invasive methods for quantifying the optical quality of the eye's retinal image from wavefront measurements and determine the relationship between retinal image quality and visual performance. The specific aims of this competitive renewal are to: 1. Test the ability of our new metrics of retinal image quality to detect change in optical disease. 2. Directly test the organizing hypothesis that a change in retinal image quality is predictive of future vision loss in optical disease. 3. Improve the power of newly developed single-valued wave aberration metrics to predict a change in visual performance by adding measurements of forward scatter. 4. Use physical and computer models to test the measurement assumptions of our new analysis of forward scatter and explore ways to improve the speed, efficiency and accuracy of our analysis. These specific aims will be accomplished by: 1. A 5-year longitudinal study of 120 patients with cataract, monitoring visual performance and retinal image quality using metrics of aberration and scatter derived from Shack/Hartmann wavefront sensing. 2. Analyzing the data to test whether our metrics can detect change over a short time period that is predictive of future loss and in the process continually improve our metrics. 3. Building both wave aberrations and forward scatter into physical and computer models to test measurement assumptions and explore ways to improve our analysis. This line of research will advance the fundamental understanding of retinal image quality and its relation to visual performance and provide a sensitive method for assessing the optical quality of the eye and monitoring therapy designed to improve the optical quality of the eye.