Building Sustainable Translational Research Teams in HIV-Associated Malignancies

描述（由申请人提供）：癌症是全球艾滋病毒感染的主要并发症之一。乌干达尤其是艾滋病毒相关恶性肿瘤发病率最高的国家之一，但乌干达对艾滋病毒相关恶性肿瘤的研究一直受到少数训练有素的科学领导人和缺乏有能力进行这一领域专门研究的研究小组的限制。2004年，弗雷德哈钦森癌症研究中心与乌干达癌症研究所（UCI）发起了一项名为乌干达癌症和传染病计划（UPCID）的合作。迄今为止，合作研究已在该领域获得了许多研究赠款和出版物。此外，我们还制定了一项成功的计划，在Fogarty国际中心的支持下，培训乌干达的医生-科学家进行艾滋病毒/艾滋病评估，培训了另外43名人员参与艾滋病毒/艾滋病评估研究，最近还获得了美国国际开发署的赠款，在UCI校园内建立了一个新的诊所和培训中心。尽管我们作出了各种努力，但在一些关键领域仍然缺乏训练有素的人员。基于乌干达对艾滋病毒/艾滋病和疟疾研究的巨大需求以及UPCID制定的强有力的合作方案，我们设计了一个方案，以扩大乌干达的艾滋病毒/艾滋病和疟疾培训。我们提出了一个由三个部分组成的培训计划：1）研究领导者的培训：为四名未来的科学领导人提供长期和短期综合培训（主要研究者）将在与艾滋病毒/艾滋病相关的四个确定领域进行为期三年的研究。（感染相关癌症、淋巴瘤、临床试验和癌症流行病学），并将在Makerere授予博士学位，其中包括华盛顿大学的课程; 2）培训研究管理人员中-短-定期培训，以培养监督和支持四个专业领域的艾滋病毒/艾滋病和疟疾临床和转化研究所需的工作人员：研究经理、数据经理、实验室经理和药房经理。培训将包括马凯雷雷大学颁发的两个正式公共卫生硕士学位，以及在延长3个月的实习期后颁发的另外6个核心能力证书; 3）研究执行人员培训：在坎帕拉进行短期培训，由西雅图和坎帕拉的教师每季度联合讲授8个学科（行政;数据管理;法规事务;临床运营;对外关系和沟通;社区事务;实验室运营;药房运营）。在奖励期结束时，58人在各级接受了艾滋病毒/艾滋病和疟疾研究方面的培训，并被编入4个小组，准备进行独立和合作研究。相关性：癌症是全世界艾滋病毒感染的主要并发症，但乌干达的艾滋病毒相关癌症负担是世界上最高的。在过去的五年里，弗雷德哈钦森癌症研究中心与乌干达癌症研究所建立了富有成效的伙伴关系。这项建议旨在培训58名乌干达人从事与艾滋病毒有关的恶性肿瘤的各级研究，建立四个研究小组，准备在该领域进行独立和合作的尖端研究。

DESCRIPTION (provided by applicant): Cancer is one of the leading complications of HIV infection worldwide. Uganda in particular has among the highest rates of HIV-associated malignancies (HIVAM), but research on HIVAM in Uganda has been limited by a small number of trained scientific leaders and a paucity of research teams with the capacity to conduct research specializing in this field. In 2004, the Fred Hutchinson Cancer Research Center initiated a collaboration with the Uganda Cancer Institute (UCI) known as the Uganda Program on Cancer and Infectious Diseases (UPCID). The collaborative research to date has resulted in a number of research grants and publications in the field. Furthermore, we have developed a successful program to train Ugandan physician-scientists in HIVAM supported by the Fogarty International Center, trained an additional 43 personnel to participate in HIVAM research, and have recently been awarded a grant to from USAID to build a new clinic and training center on the UCI campus. Despite all of our efforts, trained personnel are still lacking in a number of crucial fields. On the foundation of the great need for HIVAM research in Uganda and the strong collaborative program developed in UPCID, we have designed a program to expand training in HIVAM in Uganda. We propose a training program with three components: 1) Training for Research Leaders: Combined long- and short-term training for four future scientific leaders (Principal Investigators) will be conducted over three years in four defined areas relevant to HIVAM research (infection-related cancers, lymphoma, clinical trials, and cancer epidemiology), and will culminate in Doctoral degrees conferred by Makerere which will include courses at University of Washington; 2) Training for Research Managers Combined long-, medium- and short-term trainings to develop the staff required to oversee and support clinical and translational research in HIVAM in four specialized disciplines: Study Managers, Data Managers, Lab Managers, and Pharmacy Managers. Training will include two formal Masters of Public Health degrees from Makerere University and six additional Certificates of Core Competency after extended 3-month internships; 3) Training for Research Implementers: Short-term trainings in Kampala taught jointly by Seattle and Kampala faculty on a quarterly basis in eight disciplines (Administration; Data Management; Regulatory Affairs; Clinical Operations; External Relations and Communications; Community Affairs; Laboratory Operations; Pharmacy Operations). At the end of the award period, 58 persons trained in HIVAM research at all levels and integrated into 4 teams will be ready to conduct independent and collaborative research. RELEVANCE: Cancer is a leading complication of HIV infection worldwide, but the burden of HIV-associated cancers in Uganda is among the highest in the world. For the past five years, the Fred Hutchinson Cancer Research Center has had a highly productive partnership with the Uganda Cancer Institute. This proposal seeks to train a total of 58 Ugandans in HIV-associated malignancy research at all levels, to establish four teams of researchers prepared to conduct independent and collaborative cutting-edge research in the field.