Understanding Cross-National Health Differences at Older Ages and Their Causes

其他项目信息-项目摘要/摘要 了解老年人群的跨国健康差异及其原因 该项目旨在促进对跨国健康差异及其原因的了解，特别是 评估卫生保健系统、覆盖范围和质量、健康行为、生活方式、收入和 财富分配和历史生活环境。了解差异和原因需要 对健康的可比衡量，不受数据收集和跨国差异的影响 报告风格。在这方面，血液样本的分析是客观健康衡量的金标准。 该项目将扩展美国早期基于血液的健康比较(基于健康和 退休研究，HRS)和英国(基于英国老龄化纵向研究，ELSA)到大陆 欧洲(根据欧洲健康、老龄化和退休调查，分享)。份额是很大的 人口代表性小组研究仿照HRS和ELSA。严格协调健康变量 这三项研究包括自我报告的健康、ADL和IADL，以及握力等体格测量 力量、峰值流量和椅子站立，以及大量的认知和心理健康测试。共享已 获得了关于医疗保健系统和生活方式、经济、工作和社会状况的非常丰富的数据 生命历程、个人健康行为史和卫生保健干预。 Share还从大约27.000名50岁及以上的受访者中收集了干血迹样本 在13个欧洲大陆国家。在最近的几波中，HRS也收集了数据库。而数据库支持系统并不完美 替代ELSA和目前由HRS获得的静脉血(VB)样本，已经取得了很大进展 最近在理解从DBSS获得的值如何与VB值相对应方面取得了进展。我们有 执行了广泛的验证，这些验证显示在更正以下项后DBSS和VB值之间紧密对齐 实验室和现场过程中发生的系统性因素。 该项目有四个具体目标： 1.利用华盛顿大学实验室的专业知识，拥有全套 在SHARE WAVE 6中收集的DBSS用于脂类小组和2型糖尿病(T2 DM)的检测 与一般健康和认知衰退相关的生物标记物。 2.将实验室分析与共享功能和主观健康、人口统计、社会和 经济数据，创建一个用户友好的数据库并将其存档。 3.协调SHARE DBS、ELSA VB、HRS DBS和VB分析得到的数据。 4.使用这些数据对跨国差异之间的关系进行统计分析 健康、经济、工作和社会环境、健康行为和保健干预。

OTHER PROJECT INFORMATION – Project Summary/Abstract Understanding Cross-National Health Differences at Older Ages and Their Causes This project aims to foster understanding of cross-national differences in health and their causes, especially evaluating differences in health care systems, coverage and quality, health behaviors, life styles, income and wealth distributions and historical life circumstances. Understanding differences and causes requires comparable measurements of health which do not suffer from cross-national differences in data collection and reporting styles. In this respect, analyses of blood samples are a gold standard of objective health measurement. The project will extend earlier blood-based health comparisons between the US (based on the Health and Retirement Study, HRS) and the UK (based on the English Longitudinal Study of Ageing, ELSA) to Continental Europe (based on the Survey of Health, Aging and Retirement in Europe, SHARE). SHARE is a large population-representative panel study modelled after the HRS and ELSA. Health variables strictly harmonized across the three studies include self-reported health, ADLs and IADLs, physical measurements such as grip strength, peak flow and chair stand, and a large battery of tests for cognition and mental health. SHARE has obtained very rich data on health care systems and life styles, on economic, work and social circumstances over the life course, and individual histories of health behaviors and health care interventions. SHARE has also collected dried blood spot samples (DBSS) from about 27.000 respondents aged 50 and older in 13 Continental European countries. HRS has also collected DBSS in recent waves. While DBSS are not perfect substitutes for the venous blood (VB) samples obtained by ELSA and currently by HRS, much progress has recently been made in understanding how values obtained from DBSS correspond to VB values. We have performed extensive validations which show a tight alignment between DBSS and VB values after correcting for systematic factors that occur during the laboratory and field processes. The project has four specific aims: 1. Capitalize upon the expertise of the laboratory at the University of Washington by having the full set of DBSS collected in SHARE wave 6 assayed for the lipid panel and type-2 diabetes mellitus (T2DM) biomarkers relevant to general health and cognitive decline. 2. Link the laboratory analyses with the SHARE functional and subjective health, demographic, social, and economic data, create a user-friendly database and archive it. 3. Harmonize the data obtained from the assays of SHARE DBS, ELSA VB and HRS DBS and VB. 4. Use these data to perform statistical analyses on the relationships between cross-national differences in health, economic, work and social circumstances, health behaviors and health care interventions.