qHTS to Identify Small Molecule GUS Inhibitors

因此，该项目旨在筛选NCATS的化学文库，以针对一种新的、与疾病相关的微生物组靶点，以确定有希望的靶点，这些靶点可以进一步开发和优化为未来的共生药物。

As such, this project aims to screen the chemical libraries at NCATS against a novel, disease relevant microbiome target to identify promising hits that can be further developed and optimized into tomorrows symbiotic drugs. During this period, the collaborative framework for this project was established. Future goals of the project team include miniaturization and optimization of a high-throughput amenable assay to enable identification of the intended GUS-targeting symbiotic drugs. Subsequent work will focus on hit validation, followed by detailed characterization of hit activity against a diverse panel of bacterial GUS enzymes. Promising hit molecules will be advanced for medicinal chemistry SAR-driven optimization to further improve their activity and selectivity.