Epidemiologic Field Studies

BCDDP：乳腺癌检测示范项目随访研究（01030）。这项研究追踪了大约6万名乳腺癌示范项目（BCDDP）的前参与者。当前的分析包括各种队列联合汇集项目。胃癌：山东省临朐地区抑制癌前病变的随机多干预试验（00446）。我们从中国农村一项为期8年的试验中收集了15年的随访数据，以确定三种治疗方法中的任何一种是否会影响胃癌发病率或特定的死亡原因。1995 - 2003年长期补充维生素（C、E、硒）和大蒜，1995年一次性服用阿莫西林/奥美拉唑。2012年发表的一篇论文显示，阿莫西林/奥美拉唑治疗在15年期间将胃癌发病率降低了39%。我们检查了亚组，并确定抗生素治疗对老年人和研究开始时患有晚期癌前胃病变的患者有效，尽管人们认为幽门螺杆菌对早期胃癌发生起作用。因此，抗生素治疗可以广泛应用于预防胃癌，而不必局限于年轻人或轻度组织病理学的人。这项工作发表于2014年。炎症性乳腺癌（IBC）病例对照研究（00314）这项病例对照研究包括在北非5个中心（1个在突尼斯，2个在埃及，2个在摩洛哥）收集的约250例IBC病例。包括两个对照组：1)250例非ibc乳腺癌病例；2)随机选取研究医院的女性住院患者（不包括乳腺癌、卵巢癌、子宫内膜癌和鼻咽癌）250例访客对照（不包括一级亲属）。该研究包括问卷调查、人体测量、唾液收集、IBC病例乳房的数码照片，以及IBC病例和非IBC乳腺癌对照组石蜡包埋肿瘤组织的收集。该研究是与内布拉斯加州大学合作进行的，表格的开发和翻译由美国国家癌症研究所协调。NCI-DCEG负责在埃及、突尼斯和摩洛哥的研究中心制定研究程序。数据收集工作于2009年3月在埃及开始，2009年8月在突尼斯开始，2011年1月在摩洛哥开始。埃及和突尼斯的数据收集于2013年9月30日停止。该项目的数据收集工作将于2016年8月在摩洛哥结束。

BCDDP: Breast Cancer Detection Demonstration Project follow-up study (01030). This study follows about 60,000 former participants in the Breast Cancer Demonstration Project (BCDDP). Current analyses include a variety of cohort consortium pooling projects. Gastric cancer: Randomized multi-intervention trial to inhibit precancerous gastric lesions in Linqu, Shandong Province (00446). We gathered fifteen year follow-up data from an 8-year trial in rural China to determine whether any of three treatments would affect gastric cancer incidence or specific causes of mortality. The treatments were long-term vitamin (C, E, and selenium) supplementation and garlic supplementation, given from 1995 to 2003, and one time administration of amoxicillin/omeprazole given in 1995. A paper published in 2012 showed that amoxicillin/omeprazole treatment reduced gastric cancer incidence by 39% over a fifteen year period. We examined subgroups and determined that antibiotic treatment was effective for older members of the population and for members with advanced precancerous gastric lesions at the beginning of the study, despite the fact that Helicobacter pylori is thought to act on early stages of gastric carcinogenesis. Thus antibiotic treatment can be applied broadly to prevent gastric cancer and need not be restricted to the young or to those with mild histopathology. This work was published in 2014. Inflammatory breast cancer (IBC) case-control study (00314) This case-control study includes approximately 250 IBC cases accrued at 5 centers in North Africa (1 center in Tunisia, 2 in Egypt, and 2 in Morocco). Two control groups are being included: 1) 250 non-IBC breast cancer cases and; 2) 250 visitor controls (excluding first-degree relatives) to randomly selected female inpatients (excluding those with breast, ovarian, endometrial, and nasopharyngeal cancer) in the study hospitals. The study involves the administration of a questionnaire, anthropometric measurements, saliva collection, digital photographs of the breasts of IBC cases, and the collection of paraffin-embedded tumor tissue for IBC cases and non-IBC breast cancer controls. The study has been conducted as a collaboration with the University of Nebraska, with forms development and translation coordinated at the National Cancer Institute-USA. The NCI-DCEG is responsible for developing study procedures at the study centers in Egypt, Tunisia, and Morocco. Data collection began in March 2009 in Egypt, August 2009 in Tunisia, and January 2011 in Morocco. Data collection in Egypt and Tunisia stopped on 09/30/2013. Data collection for the project will end in Morocco by August 2016.