Resource Core (RC)

CPOC摘要/摘要 临床和人口结果核心(CPOC)促进采用多学科方法进行评估 OAIC临床研究的机动性和平衡性通过三个关键功能：(I)让老年人从 社区和长期护理机构作为参与者(在一系列大型登记册中)和合作伙伴 (通过我们的社区咨询委员会)进行研究；。(Ii)为调查人员提供适当的培训 与老年人口进行研究的接触、筛选和同意战略；以及(Iii)分享 临床评估方法(通过标准化的评估工具和研究数据集) 机动性、平衡性和跌倒。核心一直具有很高的生产力。在过去的5年里，CPOC提供了 支持13个试点或发展项目，包括为5名区域经济共同体见习飞行员提供咨询。我们的支持已经 向8个新资助的赠款(4个R01，2个K01，1个VA，1个基金会)捐款，并支持了40多个 独立出资的外部项目。CPOC的支持已经出版了200多种出版物。CPOC 成功启动白金长期护理登记处(居住在辅助生活和有技能的老年人 已同意研究联系的护理机构)，有40多个机构招聘地点和400多个 居民注册。CPOC社区注册处包括2500多名年长参与者，并一直是 60项研究的关键招聘来源。CPOC智能中心提供临床研究空间 并作为由 集成系统核心，我们的新型移动实验室利用非侵入性、便携技术 检查运动量、平衡性和野外体力活动。在续签中，我们将1)增加招聘和 研究人员使用胡椒长期护理-白金和社区登记，通过简化的网络 获取和监督；2)通过与我们的PCORI的伙伴关系，扩大传播--执行工作-- 资助以患者为导向的“故事展台”计划；3)通过增加额外的 调查工具，包括肌肉和脂肪的动作描记和超声评估；以及4)实施 开发试点，与同事在 我们的工程学院将开发基于计算机的自动化方法来审计谷歌街景 与老年人的行动能力和跌倒最相关的环境特征的图像。建议数 发展试点将提供有关外部物理环境的重要信息，这是一个被忽视的领域 以防跌倒风险。核心领导继续由史蒂文·M·阿尔伯特博士领导，现在包括安德里亚·罗索博士， 他将共同指导并领导我们的发展项目。

CPOC Summary/Abstract The Clinical and Population Outcomes Core (CPOC) promotes a multidisciplinary approach to the assessment of mobility and balance in OAIC clinical research through three key functions: (i) engaging older adults from the community and long-term care settings as participants (in a series of large-scale registries) and partners (through our Community Advisory Board) in research; (ii) providing training to investigators on appropriate contact, screening, and consent strategies for research with older populations; and (iii) sharing expertise in clinical assessment methodology (though a standardized library of assessment tools and study datasets) for mobility, balance, and falls. The Core has been highly productive. Over the past 5 years CPOC has provided support for 13 pilot or developmental projects, including consultation for 5 REC trainee pilots. Our support has contributed to 8 newly funded grants (4 R01, 2 K01, 1 VA, 1 foundation) and has supported over 40 independently funded external projects. CPOC support has resulted in over 200 publications. CPOC successfully launched the Platinum Long-Term Care Registry (seniors residing in assisted living and skilled nursing facilities who have consented to research contact), with over 40 facility recruitment sites and over 400 residents enrolled. The CPOC Community Registry includes over 2500 older participants and has served as a key recruitment source for 60 research studies. The CPOC SMART Center provides clinical research space and serves as a testbed for a number of innovative devices and experimental paradigms designed by the Integrative Systems Core, and our novel mobile laboratory utilizes noninvasive, portable technology to examine mobility, balance, and physical activity in the field. In the renewal we will 1) increase recruitment and researcher use of the Pepper Long-Term Care-Platinum and Community Registries, with streamlined web access and oversight; 2) expand dissemination-implementation efforts through a partnership with our PCORI- funded patient-oriented “Story Booth” program; 3) expand our mobile laboratory by adding additional investigative tools, including actigraphy and ultrasound assessment of muscle and fat; and 4) implement a developmental pilot, “Automated Neighborhood Walkability Audits by Machine Learning,” with colleagues in our School of Engineering to develop computer-based, automated methods for auditing Google Street View images for environmental features most relevant to mobility and falls in older adults. The proposed developmental pilot will provide important information on external physical environments, a neglected domain for falls risk. Leadership of the Core continues with Dr. Steven M. Albert and now includes Dr. Andrea Rosso, who will co-direct and also lead our developmental project.