Pilot Projects

试点项目计划摘要 试点项目方案的设计是基于提高科学步伐的长期愿景， 佛蒙特州免疫学和传染病中心（VCIID）的合作和竞争力。 这与我们第三阶段COBRE计划的总体目标是一致的，即促进向 独立的可持续发展中心，可以竞争合作R 01，P01，U19和SBIR/STTR赠款。 基于我们在第一阶段和第二阶段发展的研究专长，以及生物医学研究的国家趋势， 我们设计了三个类别的试点项目，以扩大VCIID的研究组合：i）基础 免疫学或微生物学研究，ii）转化研究，iii）创业SPARK-VT 通过诊断或治疗将想法从基础研究转移到商业部门的计划 平台在这三个类别中，重点将放在初级调查员和合作方面， 无论是在VCIIID COBRE教师以及与其他COBRE计划，如佛蒙特州肺中心 (VLC)或附近的盖泽尔/达特茅斯医学院免疫学/微生物学科布雷。严格的 申请和审查过程将使用NIH指南实施，以确定最有价值的 科学，并选择具有长期成功潜力的申请人。此外，试点项目 该计划将通过为初级教师提供更优惠的工资线来满足他们的需求， 分配指导。具体目标如下： 具体目标1。实施试点项目计划。我们将为VCIID教师提供试点项目资金， 为新的赠款获取关键数据，重点是与本项目和其他COBRE项目的研究人员合作 方案，使用核心设施，并提供个性化的指导。 具体目标2。对试点项目进行严格评估，以促进出版和赠款 意见书。我们将使用NIH格式的书面申请，然后进行口头陈述的最 对外部咨询委员会（EAC）的贡献。在那些具有高科学价值的人中， 给予初级教师和合作教师。 具体目标3。围绕试点项目的共同研究主题建立P01/U-19工作组 赠款。围绕i）病毒性传播的共同研究主题，成立了由指定领导人组成的工作组 免疫学，ii）免疫应答的代谢调节，iii）免疫应答的计算建模， 系统，iv）寄生虫的小分子靶标，和v）对感染性和 自身免疫性疾病这些团体可以获得试点资金，以获得合作所需的关键数据。 R 01、P01、U19或SBIR/STTR赠款。

SUMMARY for the Pilot Project Program The design of the Pilot Project Program is based on the long-term vision of enhancing the scientific pace, collaboration, and competitiveness of the Vermont Center for Immunology and Infectious Diseases (VCIID). This is consistent with our overall objective of the Phase III COBRE program to promote the transition to an independent sustainable center that can compete for collaborative R01, P01, U19, and SBIR/STTR grants. Based on our developed research expertise during Phases I and II, and national trends in biomedical research, we have designed three categories of Pilots Projects to expand the VCIID's research portfolio: i) basic research in immunology or microbiology, ii) translational research, and iii) an entrepreneurial SPARK-VT Program to move ideas from basic research into the commercial sector through diagnostic or therapeutic platforms. Emphasis among these three categories will be given to junior investigators and collaborations, both within VCIID COBRE faculty as well as with other COBRE programs, such as the Vermont Lung Center (VLC) or the nearby Geisel/Dartmouth Medical School COBRE in Immunology/Microbiology. A rigorous application and review process will be implemented using NIH guidelines to identify the most meritorious science, and to select applicants with the greatest potential for long-term success. In addition, the Pilot Project Program will be responsive to the needs of junior faculty by providing them with a more favorable pay line, and assigned mentoring. The Specific Aims are thus: Specific Aim 1. Implement a Pilot Project Program. We will provide Pilot Project funds to VCIID faculty to secure critical data for new grants, with emphasis on collaborations with investigators in this and other COBRE programs, use of core facilities, and with the provision of personalized mentoring. Specific Aim 2. Provide rigorous evaluation of Pilot Projects to promote publications and grant submissions. We will use an NIH format of written applications followed by oral presentations of the most meritorious to the External Advisory Committee (EAC). Among those with high scientific merit, preference will be given for junior faculty and collaborating faculty. Specific Aim 3. Foster P01/U-19 working groups around common research themes of the Pilot Project Grants. Working groups with appointed leaders have been formed around common research themes in i) viral immunology, ii) metabolic regulation of the immune response, iii) computational modeling of the immune system, iv) small molecule targets for parasites, and v) sex differences in susceptibility to infectious and autoimmune diseases. These groups could receive pilot funding to get critical data needed for collaborative R01, P01, U19, or SBIR/STTR grants.