Administrative Core

项目摘要 核心A的目的是监督各机构的行政责任， 本P01项目1、2和3中概述的实验室研究。核心A将提供 为项目提供高级别的组织支持，包括提供必要的 资源、财政监督、遵守机构和NIH指南/法规。 核心A将进一步协调定期联席会议，以传播成果， 科学挑战，并发现创新的解决方案，以推动科学。芯A 将有助于整合样本收集和临床因素分析的科学努力 在项目内部和项目之间，通过（i）样本跟踪的协调和（ii） 为所有3个项目与国内外机构进行检索和数据收集 DFCI。核心A还负责提交/维护监管 与样品有关的文件。核心A将进一步促进 对科学界有重大意义的研究成果。这些活动将有助于 加强项目内部和项目之间丰富的科学成果的整合， 促进将发现转化为患者护理环境;相反， 来自临床观察和组织样本的实验室研究， 所有3个项目。总之，项目的这一中心资源将加强互动 在调查小组中，以进一步实现这一目标的翻译目标和愿景， 整合CLL患者的基因组、功能和临床信息的计划。

Project Summary The purpose of Core A is to oversee the administrative responsibilities of the various laboratory studies outlined in the Projects 1, 2 and 3 in this P01. Core A will provide high-level organizational support for the Projects, including provision of necessary resources, fiscal oversight, adherence to institutional and NIH guidelines/regulations. Core A will further coordinate regular joint meetings to disseminate results, discuss scientific challenges, and discover innovative solutions to advance the science. Core A will serve to integrate scientific efforts for sample collection and clinical factor analysis within and between Projects through the (i) coordination of sample tracking and (ii) the retrieval and data collection for all 3 Projects with institutions both within and outside of DFCI. Core A also has responsibility for the submission/maintenance of regulatory documents related to samples. Core A will further promote the rapid dissemination of significant research findings to the scientific community. These activities will serve to enhance the integration of the rich scientific efforts within and between Projects, and foster the translation of findings to the patient care setting; and conversely, the initiation of laboratory studies stemming from clinical observations and tissue samples obtained in all 3 projects. Altogether, this central resource for the Projects will enhance interactions among the investigative teams to further the translational goals and vision of this Program for integrating genomic, functional and clinical information of CLL patients.