CENTRALIZED OMICS RESOURCE (CORE) YEAR 4

Centralized Omics REsource（CORE）Technologies是一个多奖项的无限交付无限数量（IDIQ），始于2015年，为全基因组测序和其他组学测量提供IDIQ合同奖励，包括DNA甲基化，RNA表达模式和代谢分析。CORE与NHLBI的总体TOPMed计划相结合，旨在发现影响疾病风险的因素和变异，识别疾病亚型，并开发更具针对性和个性化的治疗方法。研究和拟议的研究设计和组学是通过同行评审选择的，是提供给11个选定的组学中心之一的批准样本;使用TOPMed批准和设计的管道处理产生的原始和处理数据，并与原始研究共享，TOPMed领域工作组中的TOPMed PI，也可用于NHLBI指导的数据存储库，以与批准的研究者共享。TOPMed研究包括多个非欧洲（代表性不足的人群）以及包括或完全是女性的研究。

Centralized Omics REsource (CORE) Technologies is a multiple award Indefinite Delivery Indefinite Quantity (IDIQ) begun in 2015 and provides IDIQ contract awards for whole genome sequencing and other omics measures, including DNA methylation, RNA expression patterns, and metabolic profiling. CORE, in conjunction with NHLBI's overarching TOPMed Program, seeks to discover factors and variants that influence disease risk, identify subtypes of disease, and develop more targeted and personalized treatments. Studies and proposed study designs and omics are selected via peer review and are approved samples supplied to one of eleven selected omics centers; the resulting raw and processed data is processed using TOPMed approved and designed pipelines and shared with originating studies, TOPMed PIs working in TOPMed domain working groups, and are also made available to NHLBI directed data repositories for sharing with approved investigators. TOPMed studies include multiple non-European (underrepresented populations) as well as studies that include or are entirely female.