ARIC - FIELD CENTER - DIVERSITY SUPPLEMENT

社区动脉粥样硬化风险研究（ARIC）于1985年启动，由两部分组成：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区的住院心肌梗死（MI）、致死性冠心病（CHD）趋势：福赛斯县，NC;杰克逊，MS;明尼阿波利斯郊区，MN;和华盛顿县，MD。2005年增加了对住院心力衰竭（HF）事件的监测。选择这些社区是为了提供城市、郊区和农村四（4）个地理位置的死亡率数据。该队列研究旨在调查来自同一社区的中年白色或非洲裔美国人中动脉粥样硬化的危险因素和自然史以及临床动脉粥样硬化的发展。这项研究招募了15,792名最初年龄在45-64岁之间的白色或非洲裔美国人参与者，并在研究的前十年接受了三年一次的临床检查（1987-1989，1990-1992，1993-1995和1996-1998），在2011-2013年进行了第五次临床检查，提供了关于身体，行为，遗传和心理社会因素的丰富数据。自1988年以来，每年联系该队列，并于2011年开始半年随访。截至2014年，研究结果已发表在1,400多篇出版物中。通过颈动脉和腘动脉B超、踝臂指数测量和视网膜摄影检查参与者是否存在亚临床动脉粥样硬化的证据，并在亚组中检查腹主动脉CT和止血因素;确定和推定的实验室风险标志物;社会经济、心理、行为和环境特征;以及遗传因素。考试包括各种组成部分，在2011-2013年期间的最近一次考试中增加了由赠款资助的详细认知功能测试组成部分。血液样本已被测定推定的生化危险因素，并储存用于病例对照研究。提取DNA并冷冻保存淋巴细胞（用于可能的永生化），用于候选基因的研究、全基因组扫描、表达和其他组学研究。在每次相应的随访检查中，存活队列的参与率分别为91%、82%、74%和65%。自基线起，还每12个月联系一次队列成员，以获得有关生命状态、当前居住地、重大疾病或损伤以及联系人之间发生的住院情况的信息，以确定临床心血管疾病（CVD）事件。在2013年12月31日末次完成随访时，队列联系率为84%。

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam during 2011-2013. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Participation of the surviving cohort was 91, 82, 74, and 65% at each of the respective follow-up examinations. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical Cardiovascular Disease (CVD) events. Cohort contact was 84% at the last completed follow-up ending on December 31, 2013.