ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT

社区动脉粥样硬化风险（ARIC）研究始于1985年，包括两个部分：社区监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗死（MI）、致死性冠心病（CHD）的趋势：北卡罗来纳州福赛斯县；杰克逊女士;明尼阿波利斯郊区，明尼苏达州；2005年增加了住院心力衰竭（HF）事件的监测。这些社区被选中提供四(4)个地理位置的数据，包括城市、郊区和农村的死亡率范围。该队列研究旨在调查来自同一社区的中年白人或非洲裔美国成年人动脉粥样硬化的危险因素、自然病史和临床动脉粥样硬化的发展。该研究招募了15792名年龄在45-64岁之间的白人或非裔美国人参与者，选定的参与者在研究的前十年（1987-1989年、1990-1992年、1993-1995年和1996-1998年）接受了三年一次的临床检查，并在2011-2013年进行了第五次临床检查，提供了一组关于身体、行为、遗传和社会心理因素的丰富数据。自1988年起，每年对该队列进行随访，2011年开始每半年随访一次。截至2014年，已有1400多份出版物发表了研究结果。通过颈动脉和腘动脉b超、踝肱指数测量、视网膜摄影以及亚组腹主动脉CT和止血因子检查参与者的亚临床动脉粥样硬化证据；已建立和假定的实验室风险标记；社会经济、心理、行为和环境特征；还有遗传因素。考试包括多种组成部分，在2011-2013年的最近一次考试中增加了一个由拨款资助的详细认知功能测试部分。对血液样本进行了假定的生化危险因素分析，并保存以供病例对照研究。DNA已被提取，淋巴细胞冷冻保存（为了可能的永生），用于候选基因的研究，全基因组扫描，表达和其他组学研究。在每次随访检查中，存活队列的参与率分别为91%、82%、74%和65%。从基线开始，每12个月与队列成员联系一次，以获取他们的生命状况、目前居住地、主要疾病或损伤以及接触者之间发生的住院情况，以确定临床心血管疾病（CVD）事件。在2013年12月31日最后一次完成随访时，队列接触率为84%。

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam during 2011-2013. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Participation of the surviving cohort was 91, 82, 74, and 65% at each of the respective follow-up examinations. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical Cardiovascular Disease (CVD) events. Cohort contact was 84% at the last completed follow-up ending on December 31, 2013.