ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT

ARIC - JHU 野外中心 - 多样性补充

• 批准号: 10054600
• 负责人: JOSEF CORESH
• 金额: $ 23.38万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054600
• 关键词: ARIC; JHU; FIELD; CENTER; DIVERSITY

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam during 2011-2013. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Participation of the surviving cohort was 91, 82, 74, and 65% at each of the respective follow-up examinations. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical Cardiovascular Disease (CVD) events. Cohort contact was 84% at the last completed follow-up ending on December 31, 2013.

社区动脉粥样硬化风险(ARIC)研究始于1985年，由两部分组成：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗死(MI)和致命冠心病(CHD)的趋势：北卡罗来纳州福赛斯县、密苏里州杰克逊、明尼阿波利斯郊区和马里兰州华盛顿县。2005年增加了对住院心力衰竭(HF)事件的监测。这些社区被选择来提供四(4)个地理位置的数据，这些地理位置的死亡率范围在城市、郊区和农村环境中。这项队列研究旨在调查同一社区的中年白人或非洲裔美国成年人中动脉粥样硬化的危险因素和自然病史以及临床动脉粥样硬化的发展。这项研究招募了15,792名白人或非裔美国人，最初年龄在45-之间，选定的参与者在研究的前十年(1987-1989年、1990-1992年、1993-1995年和1996年-1998年)接受了三年一次的临床检查，2011年-2013年进行了第五次临床检查，提供了关于身体、行为、遗传和心理社会因素的丰富数据集。自1988年以来，每年都与该队列进行联系，并于2011年启动了半年一次的后续行动。截至2014年，已有1400多份出版物发表了这一研究结果。受试者接受了颈动脉和月国动脉的B型超声、踝臂指数测量和视网膜照相以及腹主动脉CT和止血因素的检查，以寻找亚临床动脉粥样硬化的证据；已建立和假定的实验室风险标记；社会经济、心理、行为和环境特征；以及遗传因素。考试包括各种组成部分，在2011-2013年间的最近一次考试中增加了拨款资助的详细认知功能测试组成部分。已经对血液样本进行了可能的生化危险因素检测，并储存起来用于病例对照研究。DNA被提取出来，淋巴细胞被冷冻保存(为了可能永生)，用于候选基因的研究、全基因组扫描、表达和其他组学研究。在各自的后续检查中，存活队列的参与率分别为91%、82%、74%和65%。自基线以来，还每12个月联系一次队列成员，以获取有关生命状态、当前居住地、重大疾病或伤害以及接触者之间住院情况的信息，以确定临床心血管疾病(CVD)事件。在2013年12月31日结束的上一次完成的随访中，队列接触率为84%。