Identification of small molecule inhibitors of USP15

鉴于USP15在肿瘤发生和T细胞活化中的作用，USP15是癌症和癌症免疫治疗的一个有希望的靶点。通过定量高通量筛选鉴定USP15特异性小分子抑制剂，并进一步开发先导化合物，不仅可以开辟新的癌症治疗策略，而且可以更好地了解USP15的生物学功能。

Given USP15s role in tumorigenesis and T cell activation, USP15 is a promising target for cancer and cancer immunotherapy. Identification of USP15-specific small-molecule inhibitors through a quantitative high-throughput screening and further development of the lead compound could not only open new strategies to tackle cancer, but allow to better understand biological functions of USP15. During this period, the project team worked to validate small molecule hits from the previously completed high-throughput screen. Using activity profiles from the orthogonal assays tested against the screening hits, the team employed a machine learning approach to conduct an in silico screen against an additional 100,000 small molecules to extend the number of prospective chemotypes with inhibitory activity against USP15.