Visible Light Photocatalysis

项目摘要/摘要 光化学合成代表着药物发现和生物医学研究的一个令人兴奋的前沿。这个 小的、结构复杂的有机分子与生物分子相互作用并扰乱其 行为是现代分子医学和化学生物学的核心。新药的发现 因此，具有新特性的生物探针关键依赖于新分子的合成。 具有前所未有的结构。长期以来，光化学一直是一门不发达的化学技术 合成，部分是因为有机分子用光照射会产生高度的 活性的、高能的物质，可以不加区别地、不产生生产力地反应。 我们正在研究在光化学反应中添加各种试剂可以控制 这些光生中间体以不同的方式产生。在这项提案中，我们描述了两个具体目标 研究这些试剂如何产生强大的新的键形成方法。 目的1.我们正在探索手性催化剂控制光化学立体化学的能力 反应。 目标2.我们正在探索铜氧化剂将官能团安装到 简单的非功能化有机支架。 这些方法实现了化学转换，否则无法使用 传统的非光化学技术。因此，我们预计我们的研究结果将具有 在基础学术化学研究和生物医学能力方面的重大影响 科学家们正在合成和发现下一代救命药物。

PROJECT SUMMARY/ABSTRACT Photochemical synthesis represents an exciting frontier for drug discovery and for biomedical research. The ability of small, structurally complex organic molecules to interact with biomolecules and perturb their behavior is at the heart of modern molecular medicine and chemical biology. The discovery of new drugs and biological probes with new properties, therefore, relies critically upon the synthesis of new molecules with unprecedented structures. Photochemistry has long been an underdeveloped technique in chemical synthesis, in part because the irradiation of organic molecules with light results in the generation of highly reactive, high-energy species that can react indiscriminately and unproductively. We are investigating the ways in which addition of various reagents to photochemical reactions can control these photogenerated intermediates in diverse ways. In this proposal, we describe two Specific Aims to study how these reagents can result in powerful new bond forming methods. Aim 1. We are exploring the ability of chiral catalysts to control the stereochemistry of photochemical reactions. Aim 2. We are exploring the ability of copper oxidants to enable the installation of functional groups onto simple unfunctionalized organic scaffolds. These methods enable chemical transformations that cannot otherwise be accomplished using conventional, non-photochemical technologies. Thus, we expect that the results of our research will have significant impacts both in fundamental academic chemical research and on the ability of biomedical scientists to synthesize and discover the next generation of life-saving drugs.