RCMI@Morgan: Center for Urban Health Disparities Research and Innovation

项目摘要 健康差距可归因于复杂的疾病，这些疾病涉及社会、环境和 遗传因素。更好地了解疾病的机制和干预措施的发展 需要最先进的研究设施，支持一流的、多学科的研究和参与 社区中的一员。研究基础设施核心(RIC)将提供管理结构， 执行多学科生物医学和健康差异研究所需的仪器和专业知识 巴尔的摩的城市环境。根据摩根州立大学目前和未来的研究需求，有三项 将建立或加强核心研究设施(CRF)：1)动物研究核心(ARC)；2.分子 和细胞生物学研究核心实验室(MCB)；和3.生物统计和生物信息学支助股 (BBSU)。为了满足行为学和基础科学研究人员的需要，ARC将由两个 不同的站点。它将由一名教员共同领导和一名核心经理管理。它将提供动物住所和 用于组织学/病理学、外科手术和行为研究的测试室和先进仪器。一个 约翰霍普金斯大学的兽医将担任ARC的成员，监督研究的健康状况 动物。MCB将由迪克森研究中心的多个实验室组成，并将进行管理 由一名联合领导和一名核心经理。它将为基因组学、流式细胞术、分子成像、 分子分析、纳米材料研究和其他前沿实验。将对BBSU进行管理 由一名教员共同领导，并由一名教员生物信息学家协助。它将提供统计和生物信息学 向研究人员提供咨询和计算资源。BBSU将设在#年RCMI办公区 波蒂奇。三个CRF将开展外联活动，定期举办培训讲习班，并将促进传播 通过出版物和协助用户进行数据分析，对研究结果进行分析。CRF将属于 大学作为共享设施，供任何密歇根州立大学的研究人员使用。由副秘书长组成的监督委员会 研究和经济发展总裁(DRED)和学校的院长(工程学， 理科和社会工作)和学院(社区卫生与政策和文科) 将就重大采购、空间分配、设施、 和人事变动。它将就美国总统和教务长的生物医学研究需求提供建议。 此外，该基金还将继续为该大学提供资金，并促进合作伙伴关系基金在RCMI资助期之后的可持续性。国际投资委员会将讨论CRF的 与领导和联合领导的运营定期进行，领导和联合领导将每月举行会议，并 有必要审查实现RIC目标的进展情况，解决任何问题，并制定战略 关于如何加强和维持不同感兴趣领域的研究。资源、培训计划、 面向教职员工和其他用户的外展努力将有助于巩固健康和健康领域的竞争性研究 摩根州立大学的差异。

Project Summary Health disparities are attributable to complex diseases that involve the interactions of social, environmental, and genetic factors. A better understanding of the mechanisms of the diseases and the development of interventions requires state-of-the-art research facilities that support top notch, multidisciplinary research and the involvement of the community. The Research Infrastructure Core (RIC) will provide the administrative structure, instrumentation, and expertise needed to perform multidisciplinary biomedical and health disparities research in the urban setting of Baltimore. Based on the current and future research needs at Morgan State University, three Core Research Facilities (CRFs) will be established or enhanced: 1) Animal Research Core (ARC); 2. Molecular and Cellular Biology Research Core Laboratory (MCB); and 3. Biostatistics and Bioinformatics Support Unit (BBSU). To meet the needs of both behavioral and basic science researchers, the ARC will consist of two separate sites. It will be managed by a faculty Co-Lead and a Core Manager. It will provide animal housing and testing rooms and advanced instrumentation for histology/pathology, surgery, and behavioral studies. A veterinary doctor from Johns Hopkins University will serve as the ARC's to oversee the health of research animals. The MCB will comprise of multiple laboratories in the Dixon Research Center and it will be managed by a Co-Lead and a Core Manager. It will provide support for genomics, flow cytometry, molecular imaging, molecular analyses, nanomaterials research, and other cutting-edge experiments. The BBSU will be managed by a faculty Co-Lead who will be assisted by a Faculty Bioinformatician. It will offer statistical and bioinformatics consultation and computational resources to researchers. The BBSU will be housed in an RCMI office area in Portage. The three CRFs will conduct outreach, regular training workshops, and will promote the dissemination of research findings through publications and by assisting users with data analyses. The CRFs will belong to the University as shared facilities for use by any MSU researcher. An Oversight Committee consisting of the Vice President for Research and Economic Development (DRED) and the deans of the schools (Engineering, Sciences, and Social Work) and colleges (Community Health and Policy and Liberal Arts) of participating faculty will provide guidance to the PI and RIC Lead on matters relating to major purchases, space allocations, facilities, and personnel changes. It will advise the president and provost on the biomedical research needs of the university and facilitate the sustainability of the CRFs beyond the RCMI funding period. The PI will discuss CRFs' operations with the Lead and Co-Leads regularly and the Lead and Co-Leads will meet monthly and as necessary to review progress towards meeting the objectives of the RIC, resolve any problems, and to strategize on how to enhance and sustain research in the different areas of interest. The resources, training programs, and outreach efforts to faculty and other users will serve to entrench competitive research in health and health disparities at Morgan State University.