Comprehensive Genomics

全面基因组学共享资源 项目摘要/摘要 综合基因组学是理解癌症的分子病理生理学和 发现改进的诊断和治疗方法。综合基因组学共享资源 新泽西州罗格斯癌症研究所(CINJ)的(基因组学)是一个制度管理的共享资源 其目的是提供集中化、高质量、成本效益高的尖端细胞基因组分析和 纸巾。 这一共享资源在上一次授予期间得到了极大的扩展，现在驻留在罗格斯大学内部 大学细胞和DNA存储库(RUCDR-无限生物)，并包括一大套下一代 测序技术。这一重组使CINJ能够解决发展下一步- 通过利用以下地址提供的重要资源和工具，实现生成排序功能 RUCDR以满足癌症中心研究人员的需求。两名训练有素和经验丰富的CINJ工作人员 成员仍然使用共享资源，现在在RUCDR内部工作，致力于服务于 癌症中心成员。两位工作人员都向联席主任汇报工作，提供当地咨询服务， 并安排无缝的样品转移。RUCDR拥有最先进的生物样品处理技术 仪器、机器人工作流程(包括用于处理来自核的样本的全自动机器人设施 从酸提取到测序)、综合质量控制和一套测序平台。定序 数据通过闪存驱动器或电子方式传输回调查人员，通常与 生物医学信息学共享资源。

COMPREHENSIVE GENOMICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT Comprehensive Genomics is integral to understanding the molecular pathophysiology of cancer and the discovery of improved diagnostics and treatments. The Comprehensive Genomics shared resource (Genomics) of Rutgers Cancer Institute of New Jersey (CINJ) is an Institutionally managed shared resource whose purpose is to provide centralized, high quality, cost-effective cutting edge genomic analyses of cells and tissues. This shared resource has been greatly expanded over the last grant period and now resides within the Rutgers University Cell and DNA Repository (RUCDR-Infinite Biologics) and includes a large suite of next-generation sequencing technologies. This reorganization allowed CINJ to address the suggestion to develop next- generation sequencing capabilities by leveraging the significant resources and instrumentation available at RUCDR to serve the needs of Cancer Center investigators. The two highly trained and experienced CINJ staff members remain with the shared resource and now work within RUCDR, dedicated to serving the needs of Cancer Center members. Both staff members report to the Co-Directors, provide local consultation services, and arrange for seamless sample transfer. RUCDR is home to state-of-the-art biosample-processing instrumentation, robotic workflows (including a fully automated robotics facility for sample handling from nucleic acid extraction to sequencing), integrated quality control, and a suite of sequencing platforms. Sequencing data is transmitted back to investigators either on flash drives or electronically, usually in coordination with the Biomedical Informatics shared resource.