CTSA KL2 Supplement Rebecca Grzadzinski

本申请是对NOT-OD-20-022的回应而提交的，作为对 NCATS CTSA计划KL2机构职业发展奖。非常成功的人 北卡罗来纳大学(UNC)机构职业发展奖KL2计划是 位于北卡罗来纳大学翻译和临床科学(TraCS)研究所内，旨在塑造 初级翻译科学家的发展，如这项建议的申请人。这个 这项提案的首要目标是描述纵向的大脑行为轨迹，以及 唐氏综合征(DS)从婴儿期到学龄期的发育特征与 自闭症谱系障碍(ASD)。具体目标是：1)描述年龄、精神障碍和 DS儿童从婴儿期到学龄期的社会交流(SC)特异性脑功能特征 2)描述DS儿童在婴儿期和学龄期的SC发展情况。这个项目是 首先，解决缺乏1)检查SC症状的开始和轨迹的研究 婴儿时期患有DS的儿童，2)在早期将SC表型与大脑特征相结合 出生后前瞻性、纵向样本和3)比较与DS之间的脑生物标志物， 婴儿期和儿童期的IASD和TD儿童。这一无与伦比的机会将产生 患有DS的儿童SC缺陷的综合轨迹利用四项赠款的数据 是婴儿大脑成像研究(IBIS)网络的一部分，使这一大规模、复杂的 项目可行。该提案涉及NCATS CTSA计划的目标，即TraCS KL2 计划和纳入计划的方式如下：1)资助该学者的项目 增加DS研究人员的翻译劳动力，2)该项目利用预期的、 患有DS、ASD和典型发育(TD)的儿童的纵向队列，从而解决 Include的目标是调查整个生命周期内的共生情况，以及3)整合 多个领域，以加快DS新疗法和干预措施的开发。 该项目的完成将带来丰富的关于SC和Brain发展的信息 DS、ASD和TD儿童的生物标志物，目的是促进新的 针对DS儿童的SC疗法和干预。

This application is submitted in response to NOT-OD-20-022 as an administrative supplement to NCATS CTSA Program KL2 Institutional Career Development Awards. The highly-successful University of North Carolina (UNC) Institutional Career Development Award KL2 program is housed within the UNC Translational and Clinical Sciences (TraCS) Institute and aims to shape the development of junior translational scientists such as the applicant of this proposal. The overarching goal of this proposal is to characterize longitudinal, brain-behavior trajectories, and developmental profiles from infancy through school-age in Down Syndrome (DS) compared to Autism Spectrum Disorder (ASD). The specific aims are to 1) characterize age-, disorder- and social communication (SC)-specific brain features in DS children from infancy through school age and 2) describe SC development during infancy and school age in DS children. This project is the first to address the lack of studies that 1) examine the onset and trajectory of SC symptoms in children with DS during infancy, 2) combine SC phenotyping with brain features in an early postnatal prospective, longitudinal sample and 3) compare brain biomarkers between with DS, iASD, and TD children both in infancy and childhood. This unparalleled opportunity to generate comprehensive trajectories of SC deficits in children with DS leverages data across four grants that are part of the Infant Brain Imaging Study (IBIS) Network making this large-scale, complex project feasible. This proposal addresses the goals of NCATS CTSA Program, the TraCS KL2 Program, and the INCLUDE Project in the following ways, 1) Funding this scholar’s project increases the translational workforce of DS researchers, 2) This project utilizes prospective, longitudinal cohorts of children with DS, ASD, and typical development (TD) thereby addressing the INCLUDE goal to investigate co-occurring conditions across the lifespan, and 3) integrates multiple fields in order to accelerate the development of new therapies and interventions for DS. Completion of this project will result in rich information about the development of SC and brain biomarkers for DS, ASD, and TD children with the aim of accelerating the development of new SC therapies and interventions for DS children.