Core B: Biorepository Core

核心B摘要 生物仓库核心创建了一流的、具有国际竞争力的基础设施，以实现最佳 管理和监督人类生物标本以支持分子中心的目标 流行病学。生物菌种是疾病及其宿主的分子特征的基础，并且 对现代分子流行病学研究至关重要。精心处理生物样品，集成良好 因此，未识别的标本编码、跟踪和数据系统对于应用尖端技术是必不可少的 快速推进我们对复杂疾病相互作用的分子基础的理解的技术。在……里面 在我们中心的第一阶段，生物库核心有效地收集、处理和平衡了超过115,000 通过实施机器人与手动配对，从21,000多个独特和多样化的生物标本中提取样本 分类系统。一个CLIA认证的核心部件，占用了我们在科布雷第一期翻新的空间 新的威廉姆森翻译研究大楼现在已经配备了按存储容量使用计费系统。我们进一步 构建了一个安全的、非现场的生物样品资源设施，以长期存储我们的高质量样本 访问和未来使用。在第一阶段取得成功的基础上，我们将扩大我们的集中式剧目 样品的服务和数量，同时保持严格的收集、处理和分析准备 现行分析和下游分析的标准(包括核酸提取)。一个不断壮大的团队 具有多学科经验的资深调查人员将提供教育、培训、咨询和 向该中心提供专业知识。我们将增强我们基于网络的交互式数据库，并使它们 更广泛地提供，并设计与临床和流行病学相联系的集成可搜索平台 数据。在第二阶段，我们将改进和逐步投入按存储容量使用计费系统，以加快我们的发展轨迹 可持续性，并将我们独特的核心资源扩展到其他IDEA计划和大规模 区域、国家和国际倡议。于是，我们建立了一个新的协调、集中的 生物库基础设施，将继续促进中心研究的科学进步 项目，并为跨学科翻译研究合作做出重大贡献 更广泛的科学界。

CORE B ABSTRACT The Biorepository Core has created a state-of-the-art and internationally competitive infrastructure for optimal management and oversight of human biospecimens to support the goals of the Center for Molecular Epidemiology. Biospecimens are the basis of the molecular characterization of both a disease and its host, and are crucial for modern molecular epidemiologic study. Careful handling of biologic samples with well-integrated de-identified specimen coding, tracking and data systems are thereby essential for applying cutting edge technologies to rapidly advance our understanding of the molecular basis of complex disease interactions. In Phase I of our Center, the Biorepository Core efficiently collected, processed, and aliquoted over 115,000 samples from over 21,000 unique and varied biospecimens by implementing robotic paired with manually triaged systems. A CLIA certified component of the Core occupying space renovated in our Phase I COBRE in the new Williamson Translational Research Building now is complete with charge back systems. We further constructed a secure, off-site Biospecimen Resource Facility to store our high quality samples for long-term access and future use. Building on our success in Phase I, we will expand our repertoire of centralized services and volume of samples while preserving rigorous collection, processing and analytic preparation (including nucleic acid extraction) standards for current and downstream analyses. A growing team of established investigators with multidisciplinary experience will provide education, training, consultation, and specialized expertise to the Center. We will enhance our interactive web-based databases and make them more widely available, and design integrated searchable platforms with linkages to clinical and epidemiologic data. In Phase II we will refine and phase-in charge back systems to accelerate our trajectory towards sustainablility and expand utilization of our unique Core resources to other IDeA programs and large-scaled regional, national, and international initiatives. Thus, we established a new coordinated, centralized Biorepository infrastructure that will continue to facilitate the scientific advancements of the Center research projects, and make significant contributions to cross-disciplinary translational research collaborations from the broader scientific community.