An Integrated System for Deep Sequencing Experiment and Analysis

描述(由申请人提供)： 项目摘要/摘要本申请申请资助Illumina Genome Analyzer IIx系统和集成的数据分析服务器，以在新泽西医学和牙科大学(UMDNJ)-新泽西医学院(NJMS)和UMDNJ-新泽西牙科学校(NJDS)建立深度测序服务。这项申请侧重于UMDNJ-NJMS和UMDNJ-NJDS的一组由NIH资助的研究人员在不同研究领域的需求，包括传染病、心血管研究、口腔生物学、衰老、癌症生物学、新陈代谢和基础生物医学科学。该系统将开展一系列项目，包括微生物基因组测序、转录组分析和蛋白质-核酸相互作用研究。该系统由具有指导核心设施经验的实验和生物信息学专家共同管理，将成为UMDNJ-NJMS和UMDNJ-NJDS的关键工具，有望将当前的研究项目推向后基因组时代。

DESCRIPTION (provided by applicant): Project Summary/Abstract This application requests funding for an Illumina Genome Analyzer IIx system with an integrated data analysis server to establish a deep sequencing service at University of Medicine and Dentistry of New Jersey (UMDNJ)- New Jersey Medical School (NJMS) and UMDNJ-New Jersey Dental School (NJDS). This application focuses on the needs of a group of NIH-funded researchers at UMDNJ-NJMS and UMDNJ-NJDS in diverse research fields, including infectious diseases, cardiovascular research, oral biology, aging, cancer biology, metabolism, and basic biomedical sciences. An array of projects will be carried out with the system, including sequencing of microbial genomes, transcriptome analyses, and studies on protein-nucleic acid interactions. Co-managed by experimental and bioinformatics experts with experience in directing core facilities, this system will be a critical instrument at UMDNJ-NJMS and UMDNJ-NJDS with the promise to catapult current research projects into the post-genomic era.