800 MHz NMR console replacement

描述(申请人提供)：为了让结构生物学家继续解决日益困难的问题，开发任何可用的技术进步是至关重要的。目前的提案要求资金为800 MHz核磁共振光谱仪购买最先进的控制台，该光谱仪安装在辛辛那提大学医学院的结构生物学/核磁共振设施中。所要求的设备将取代已有14年历史的前一代控制台，并将显著提高NIH资助的一系列研究项目的性能。使用800核磁共振仪器的研究人员目前正在心血管研究、生物膜形成、囊性纤维化、肾脏疾病和炎症过程等领域进行与健康相关的研究。其他项目的重点是了解基本的生物过程，如细胞信号机制和分子识别。所有这些应用都将大大受益于最新一代核磁共振仪器可实现的更高的灵敏度、可靠性和光谱保真度。新的控制台还将允许使用目前安装在800 MHz磁体中的低温冷却探头获得最佳结果。

DESCRIPTION (provided by applicant): In order for structural biologists to continue to tackle increasingly difficult problems, it is vital to exploit whatever technological advances are available. The current proposal requests funds to purchase a state-of-the-art console for the 800 MHz NMR spectrometer that is housed in the structural biology/NMR facility within the University of Cincinnati College of Medicine. The requested equipment will replace a 14 year old, prior generation console, and will significantly enhance the performance of a wide range of NIH-funded research projects. Investigators using the 800 NMR instrument are currently pursuing health-related studies in areas such as cardiovascular research, biofilm formation, cystic fibrosis, kidney disease and inflammatory processes. Other projects are focused on understanding fundamental biological processes such as cellular signaling mechanisms and molecular recognition. All of these applications will benefit significantly from the improved sensitivity, reliability and spectral fidelity achievable with the latest generation of NMR instrumentation. The new console will also allow optimal results to be obtained with the cryogenically cooled probe that is currently installed in the 800 MHz magnet.