Pharmaceutical Research Center

描述(申请人提供)：药物研究中心：本申请旨在继续发展佛罗里达农工大学药物研究中心(FAMU)。以前资助的有针对性的研究活动证明了生产率，并产生了重大发现，这些发现已经授予了几项专利，并有更多待定的发现。根据对目前研究基础设施的评价和该方案的战略需求，建议将有针对性的活动转变为核心研究设施的开发。目前应用的主要目标是建立研究计划的基础设施，以便更好地了解分子系统的机械细节。RCMI中心将致力于基因表达分析、蛋白质组学、聚合酶链式反应分析、基因传递系统和DNA等方法的研究。 微阵列技术。在分子神经生物学、细胞成像、神经化学/受体、流式细胞仪和纳米医学领域的核心设施的建立将提高我们了解分子系统的机制细节的能力，并提供对不同分子在疾病和不利条件下如何调节的更深入的见解。药物研究中心将由一个研究行政部门和四(4)个核心服务提供设施组成。行政部门将继续提供授奖前和授奖后的援助，协调外部和内部咨询委员会的活动，提供科学研讨会和赠款研讨会，协调新的结构化指导方案，促进对方案结果的广泛外部评估，协助教师发展，雇用研究教员和市场，并举办现场赠款管理研讨会和年度RCMI R01科学家研讨会系列。具体目标一(1)是将该计划从目前在神经科学、药物输送和分子生物学方面的研究计划转变为以神经变性研究、纳米医学研究、药物发现和生物技术：疾病预防和治疗途径为重点的研究核心。通过这个核心设施网络，药物研究中心将促进跨学科和跨学科的研究。目标二(2)是提高研究人员的能力和竞争力，以获得四(4)名研究人员发起的赠款。目标三(3)是通过全面、形成性和终结性的评估过程，确保完成方案目标和成果。目标四(4)是通过重点研究那些对弱势群体产生不利影响的条件，并培养更多的少数群体科学家来解决健康差距问题，从而解决健康差距问题。这项RCMI计划已经在FAMU实现了转型。确保翻译研究处于拟议研究活动的前沿，因为我们寻求加快利用我们的生物医学发现。该学院的座右铭是“资助治疗和拯救生命”。

DESCRIPTION (provided by applicant): Pharmaceutical Research Center: This application seeks to continue the evolution of the Pharmaceutical Research Center at Florida A&M University (FAMU). The previously funded targeted research activities have demonstrated productivity and resulted in significant discoveries that have led to the award of several patents and additional pending discoveries. Based on the evaluation of the current research infrastructure and the strategic needs of the program, it is proposed to transition the targeted activities into the development of Core research facilities. The main objective of the current application is to build the infrastructure of the research program towards more understanding of the mechanistic details of the molecular system. This RCMI center will focus efforts on approaches, i.e., gene expression analysis, proteomics, PCR analysis, gene delivery systems and DNA picroarray techniques. The establishment of Core facilities in the areas of molecular neurobiology, cellular imaging, neurochemistry/receptors, flow cytometry and nanomedicine will increase our abilities to understand the mechanistic details of the molecular system and to provide greater insights into how the different molecular are modulated under disease and adverse conditions. The Pharmaceutical Research Center will consist of a research administrative component coupled with four (4) core service delivery facilities. The administrative component will continue to provide pre- and post- award assistance, coordinate the activities of the external and internal advisory committee, provide scientific seminars and grants workshops, coordinate a new structured mentoring program, facilitate an extensive external evaluation of program outcomes, assist in faculty development, hire a research faculty member and market and conduct an on-site grants management workshop and the annual RCMI R01 Scientist Seminar Series. Specific aim one (1) is to transition the program from the current research programs in neuroscience, drug delivery, and molecular biology to research cores focusing on Neurodegeneration research, Nanomedicine research, drug discovery and biotechnology: pathways to disease prevention and therapy. Through this network of Core facilities, the Pharmaceutical Research Center will foster inter- and inter-disciplinary research. Aim two (2) is to increase research investigators capabilities and competitiveness to receive four (4) investigators initiated grants. Aim three (3) is to assure the completion of program objectives and outcomes through a comprehensive formative and summative evaluation process. Aim four (4) is to address health disparities through research emphasis on those conditions that adversely impact disadvantaged populations and produce additional minority scientists who will address disparities. This RCMI Program has been transformational at FAMU. Ensuring translational research is at the forefront of the proposed research activities as we seek to accelerate the utilization of our biomedical discoveries. The College's motto is "Funding Cures and Saving Lives."