RESEARCH ADMINISTRATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 佛罗里达农工大学少数民族院校研究中心(RCMI) 摘要 这项申请寻求继续发展的药物研究中心在佛罗里达农工大学(FAMU)。以前资助的有针对性的研究活动证明了生产率，并产生了重大发现，这些发现已经授予了几项专利，并有更多待定的发现。根据对目前研究基础设施的评价和该方案的战略需求，建议将有针对性的活动转变为核心研究设施的开发。目前应用的主要目标是建立研究计划的基础设施，以便更好地了解分子系统的机械细节。这个RCMI中心将专注于各种方法，即基因表达分析、蛋白质组学、聚合酶链式反应分析、基因传递系统和DNA微阵列技术。在分子神经生物学、细胞成像、神经化学/受体、流式细胞仪和纳米医学领域的核心设施的建立将提高我们了解分子系统的机制细节的能力，并提供对不同分子在疾病和不利条件下如何调节的更深入的见解。药物研究中心将由一个研究行政部门和三(3)个核心服务提供设施组成。行政部门将继续提供授奖前和授奖后的援助，协调外部和内部咨询委员会的活动，提供科学研讨会和赠款研讨会，协调新的结构化指导方案，促进对方案结果的广泛外部评估，协助教师发展，雇用研究教员和市场，并举办现场赠款管理研讨会和年度RCMI R01科学家研讨会系列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Florida A&M University (FAMU) Research Center in Minority Institutions (RCMI) Abstract This application seeks to continue the evolution of the Pharmaceutical Research Center at Florida A&M University (FAMU). The previously funded targeted research activities have demonstrated productivity and resulted in significant discoveries that have led to the award of several patents and additional pending discoveries. Based on the evaluation of the current research infrastructure and the strategic needs of the program, it is proposed to transition the targeted activities into the development of Core research facilities. The main objective of the current application is to build the infrastructure of the research program towards more understanding of the mechanistic details of the molecular system. This RCMI center will focus efforts on approaches, i.e., gene expression analysis, proteomics, PCR analysis, gene delivery systems and DNA microarray techniques. The establishment of Core facilities in the areas of molecular neurobiology, cellular imaging, neurochemistry/receptors, flow cytometer and Nanomedicine will increase our abilities to understand the mechanistic details of the molecular system and to provide greater insights into how the different molecular are modulated under disease and adverse conditions. The Pharmaceutical Research Center will consist of a research administrative component coupled with three (3) core service delivery facilities. The administrative component will continue to provide pre- and post- award assistance, coordinate the activities of the external and internal advisory committee, provide scientific seminars and grants workshops, coordinate a new structured mentoring program, facilitate an extensive external evaluation of program outcomes, assist in faculty development, hire a research faculty member and market and conduct an on-site grants management workshop and the annual RCMI R01 Scientist Seminar Series.