RESEARCH ADMINISTRATION

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 佛罗里达A & M大学（FAMU）少数民族机构研究中心（RCMI） 摘要 本申请旨在继续佛罗里达A & M大学（FAMU）药物研究中心的发展。以前资助的有针对性的研究活动已显示出生产力，并产生了重大发现，导致授予了几项专利和其他未决发现。 基于对当前研究基础设施的评估和该计划的战略需求，建议将有针对性的活动转变为核心研究设施的发展。 当前应用的主要目标是建立研究计划的基础设施，以更好地了解分子系统的机械细节。 该区域海事委员会中心将集中努力采取各种办法，即，基因表达分析、蛋白质组学、PCR分析、基因递送系统和DNA微阵列技术。在分子神经生物学，细胞成像，神经化学/受体，流式细胞仪和纳米医学领域的核心设施的建立将提高我们理解分子系统的机制细节的能力，并提供更深入的了解疾病和不良条件下不同分子是如何调节的。 药物研究中心将包括一个研究行政部门以及三（3）个核心服务提供机构。行政部门将继续提供奖前和奖后援助，协调外部和内部咨询委员会的活动，提供科学研讨会和赠款讲习班，协调新的结构化辅导计划，促进对计划成果的广泛外部评估，协助教师发展，聘请一名研究教员和市场，并进行现场赠款管理研讨会和年度RCMI R01科学家研讨会系列。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Florida A&M University (FAMU) Research Center in Minority Institutions (RCMI) Abstract This application seeks to continue the evolution of the Pharmaceutical Research Center at Florida A&M University (FAMU). The previously funded targeted research activities have demonstrated productivity and resulted in significant discoveries that have led to the award of several patents and additional pending discoveries. Based on the evaluation of the current research infrastructure and the strategic needs of the program, it is proposed to transition the targeted activities into the development of Core research facilities. The main objective of the current application is to build the infrastructure of the research program towards more understanding of the mechanistic details of the molecular system. This RCMI center will focus efforts on approaches, i.e., gene expression analysis, proteomics, PCR analysis, gene delivery systems and DNA microarray techniques. The establishment of Core facilities in the areas of molecular neurobiology, cellular imaging, neurochemistry/receptors, flow cytometer and Nanomedicine will increase our abilities to understand the mechanistic details of the molecular system and to provide greater insights into how the different molecular are modulated under disease and adverse conditions. The Pharmaceutical Research Center will consist of a research administrative component coupled with three (3) core service delivery facilities. The administrative component will continue to provide pre- and post- award assistance, coordinate the activities of the external and internal advisory committee, provide scientific seminars and grants workshops, coordinate a new structured mentoring program, facilitate an extensive external evaluation of program outcomes, assist in faculty development, hire a research faculty member and market and conduct an on-site grants management workshop and the annual RCMI R01 Scientist Seminar Series.