USING GFR TO MEASURE THE EFFECT OF RADIO-OPAQUE CONTRAST MEDIA ON RENAL FUNCTIO

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Radio-opaque contrast media (CM) can be nephrotoxic, as measured by changes in serum creatinine. However, this value does not change until the glomerular filtration rate (GFR) is significantly lowered. Hence, the incidence of toxicity may be underestimated. This study will determine changes in GFR induced by CM. Three hours prior to the study, GFR will be determined. The investigators will use small amounts of CM and analyze plasma concentration three hours later by a validated method. They will study 30 patients, none of whom have known renal dysfunction. This study was recently initiated; no results are yet available.