AFFECTIVE INSTABILITY AND PROTEIN KINASE C SIGNAL TRANSDUCTION PATHWAYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议研究的主要目的是确定人格障碍患者的情感不稳定(A1)特征是否与血小板蛋白激酶C(PKC)活性水平有关，这一水平不同于健康对照组和没有有效不稳定的人格障碍患者。第二个目标是确定用丙戊酸盐或奥氮平治疗有情感不稳定的人格障碍患者是否会使PKC活性正常化，以及这种正常化的程度是否与症状改善相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the proposed study is to determine whether the trait of affective instability (A1) in patients with personality disorders is associated with levels of platelet protein kinase C (PKC) activity which differ from that seen in healthy controls and in personality disorder patients without effective instability. The secondary objective is to determine whether treatment of personality disorder patients who have affective instability with valproate or olanzepine will normalize PKC activity and whether the degree of this normalization correlates with symptomatic improvement.