CLINICAL TRIAL: CD4 T-CELL IMMUNE RESPONSE TO INACTIVATED INFLUENZA VACCINE IN C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是比较儿童组和成人组在基础、接种后7-10天和接种后2个月的CD4T细胞应答和血凝抑制(HAI)滴度。大约30名受试者-15名5-9岁的健康儿童和15名18-49岁的健康成年人将在2-3个月内登记参加。 本研究的主要目的是比较15名健康5-9岁儿童和15名18-49岁健康成人在接种疫苗后第7-10天和2个月时的CD4T细胞应答。 第二个目标是确定这些儿童和成人的血凝抑制(HAI)效价，并在疫苗接种后2个月，使用与T细胞研究相同的血液样本，对TIV中的三个分离株进行检测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Purpose of this study is to compare the CD4 T-cell response and the hemagglutination inhibition (HAI) titer basally, at day 7-10 post-vaccination, and at 2 months post-vaccination in the children and adult groups. Approximately 30 subjects - 15 healthy children aged 5-9 years and 15 healthy adults aged 18-49 years will be enrolled in a 2-3 month period. The primary objective of this study is to compare the CD4 T-cell responses basally, at day 7-10 post-vaccination, and at 2 months post-vaccination in 15 healthy 5-9 year-old children with those of 15 healthy 18-49 year-old adults. The secondary objective is to determine the hemagglutination inhibition (HAI) titer of these children and adults basally, and at 2 months post-vaccination for each of the three isolates contained in TIV using the same blood samples as that employed for the T-cell studies.