GUT MICROBIOTA AND HUMAN ENERGY EXPENDITURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设： 我们建议在一小群健康的正常志愿者中进行实验，以验证我们的主要假设：微生物群诱导人类总EE及其组分（特别是静息EE）显著增加。 具体目标： 1.测定紧肠前后的全身能量消耗。 2.确定微生物群在静息EE、DIT和活动EE中的贡献。 3.如果我们的假设是正确的，那么我们的目标是确定微生物群在确定瘦和肥胖个体之间的能量差异方面的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: We propose to conduct an experiment in a small group of healthy normal volunteers to test our primary hypothesis: microbiota induces a significant increase in total EE and its components (particularily in resting EE) in humans. Specific Aimes: 1. To determine the whole-body energy expenditure before and after bowel clensing. 2. To define the contributions of microbiota in resting EE, DIT, and activity EE. 3. If our hypothesis is correct, we will then aim to determine the influence of the microbiota in determining energetic differences between lean and obese individuals.