ANGER EXPRESSION, OPIOID DYSFUNCTION, AND CHRONIC PAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项工作的广泛目的是探索阿片类药物作为高特质愤怒个体由行为愤怒表达引发的镇痛的中介机制。在实验室观察到的这些效应对体内慢性疼痛强度的影响尚不清楚。试点工作表明，这些影响可能是基因调节的，这项研究将进一步探索这一可能性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The broad aim of this work is to explore opioid mechanisms as a mediator of the analgesia triggered by behavioral anger expression in individuals high in trait anger-out. The impact of these effects observed in the laboratory on chronic pain intensity in vivo are unknown. Pilot work suggests possible genetic moderation of these effects, and this study will further explore this possibility.