Administrative Core: U19

管理核心项目摘要： 这种创新的综合系统生物学应用旨在描绘复杂的宿主/病原体相互作用 发生在肺泡水平，导致对严重肺炎的治疗反应不成功。的 行政核心将负责管理、协调和监督整个范围内的CIMT 系统生物学中心活动。因此，行政核心将与所有内部行政核心小组交叉， 研究人员以及NIAID赞助机构，其他系统生物学中心，以及更广泛的传染病研究中心。 疾病和肺部/重症监护科学界。生物技术系统生物学中心有意 多学科，增加了互动的复杂性，并要求采取集中的办法， 实现这个系统生物学中心的目标。行政核心将实现这些目标 三个相互关联的具体目标：目标1。提供行政和组织 基础设施，以促进在拟议的时间表内实现可持续发展技术目标，并传播 研究项目和核心的产出。这将包括提交的生物系统 将输出集中到NIAID指导的公共数据库/存储库。AIM 2.协调和整合两者 系统生物学中心研究项目。AIM 3.组织本地和外部推广计划 以促进系统生物学方法治疗传染性肺炎。这包括将联合国贸易和发展会议 系统生物学中心纳入当前当地的培训计划，提交申请戈登研究 会议或类似会议，用于研究肺炎的系统生物学方法的研讨会， 向美国胸科学会提出了一项关于系统生物学方法的研究生课程的建议， 肺炎的主要前提下，系统生物学中心的研究议程是一个迭代的方法 基于高通量组学方法的结果和结果的建模来研究宿主/病原体相互作用。 因此，我们希望先前的结果将推动后续的实验。整合和促进这些 不同的核心和研究人员之间的后续实验将是主要责任， 行政核心。行政核心的调查员还将确保项目产生的数据 和核心是传播的格式，是有用的肺炎研究人员的更大的社区。

Admin Core Project Summary: This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The Administrative Core will be responsible for managing, coordinating, and supervising the entire range of SCRIPT Systems Biology Center activities. As such, the Administrative Core will intersect with all internal SCRIPT investigators as well as the NIAID sponsoring agency, other Systems Biology Centers, and the broader infectious diseases and pulmonary/critical care scientific communities. The SCRIPT Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The Administrative Core will accomplish these objectives in three interrelated specific aims: AIM 1. To provide the administrative and organizational infrastructure to facilitate accomplishment of the SCRIPT goals within proposed timelines, and to disseminate the output of the Research Projects and Cores. This will include the submission of SCRIPT Systems Biology Center output to NIAID-directed public databases/repositories. AIM 2. To coordinate and integrate the two SCRIPT Systems Biology Center Research Projects. AIM 3. To organize local and external outreach programs to promote a systems biology approach to infectious pneumonia. This includes integration of the SCRIPT Systems Biology Center into current local training programs, submission of an application to Gordon Research Conference or similar conference for a research symposium on a systems biology approach to pneumonia and a proposal to the American Thoracic Society for a post graduate course on Systems Biology Approaches to Pneumonia. The major premise of the SCRIPT Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. Investigators in the Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia researchers.