Mouse Genetics Core

摘要 小鼠模型提供了高度易处理的模型，用于评估、鉴定和机械表征 遗传变异对传染病反应的作用。小鼠遗传学核心已经在 设计实验交叉，序列数据集和其他小鼠资源的最前沿， 研究和扰动多态免疫网络。在鉴定多态性宿主之后 基因组区域、异常小鼠品系和不一致的免疫扩散或候选基因和途径 来自人类研究（与项目和系统遗传学和生物信息学密切合作 核心），我们将为项目制作各种小鼠实验模型，以进一步评估、识别和 描述这些过程。这些模型将包括对比变异疾病等位基因、F2 绘制种群和具有修饰的候选基因的小鼠品系。同时，设计 研究病毒性疾病的适当实验需要了解潜在的免疫机制， 个人的组成。因此，核心将识别和进一步表征影响基因的遗传变异， 基础免疫应答;细胞内以及整个生物体水平。这些数据将 提供给项目，以加强他们对抗病毒和/或干扰反应的评估。

Abstract Mouse models provide highly tractable models with which to assess, identify and mechanistically characterize the role of genetic variants on infectious disease responses. The Mouse Genetics Core has been at the forefront of designing experimental crosses, sequence datasets and other mouse resources with which to investigate and perturb polymorphic immune networks. Following the identification of polymorphic host genome regions, aberrant mouse lines, and discordant immune spreads or candidate genes and pathways from human studies (in close collaboration with the Projects and the Systems Genetics and Bioinformatics core), we will generate a variety of mouse experimental models for the Projects to further assess, identify and characterize these processes. These models will include F1 panels contrasting variant disease alleles, F2 mapping populations, and mouse strains with modified candidate genes. Concurrently, designing the appropriate experiments for the study of viral disease requires an understanding of the underlying immune composition of individuals. Therefore, the Core will identify and further characterize genetic variants impacting basal immune responses; both intra-cellular as well as at the whole-organism level. These data will be provided to the projects to enhance their assessment of antiviral and/or perturbed response.