Advanced Fabrication and Testing Core

总结 作为SC-TRIMH的一个组成部分，先进制造和测试（AFT）核心收获和 巩固了克莱姆森大学独特的工程优势和能力，以支持大三学生 研究者项目，并加快他们的创新转化为患者的具体诊断和治疗 在细胞/分子、组织和身体水平上对肌肉骨骼疾病的影响。AFT核心的总体目标是 建立基于3D模型的设计、快速原型和高级测试的集中资源， TRIMH研究人员使他们的翻译肌肉骨骼研究。具体目标 包括：目标1 -通过AFT的设计和快速原型作用，使TRIMH研究人员能够快速 设计和建立一个模拟的肌肉骨骼组件，系统或环境，是一个物理和 人体模型的生物复制品，以验证虚拟人体试验模型。为此提供的核心服务 包括机械设计、CAD绘图、工艺优化和快速3D打印（纳米、微观和宏观 设计的部件）。目标2 -通过AFT的传感器、仪器和测试作用， 研究人员设计、制造和安装传感器到物理/生物复制品上， 各种参数的测量和模型的验证。协助这些产出的核心服务包括 传感器设计，制造和安装，光学和电气设计，仪器仪表，数据采集，信号 处理和高级测试/验证。目标3 -促进AFT成为领先的集中式、可持续的 生物医学工程资源，特别是肌肉骨骼相关的研究在克莱姆森大学，南 卡罗莱纳，以及更远的地方。AFT核心将由一个由两名工程师组成的多学科团队领导。 （机械和电气）教授在机械/光学/电气设计的综合专业知识， 先进制造、快速成型、传感器、仪器仪表、成像和先进测试。的 COBRE基金将支持有经验的工作人员运营/维护综合设施， 培训/指导TRIMH研究者将他们的创新转化为临床成功，并促进 AFT核心项目向有竞争力且自我维持的项目过渡。

SUMMARY As an integral part of the SC-TRIMH, the Advanced Fabrication and Testing (AFT) Core harvests and consolidates the unique engineering strengths and capabilities at Clemson University to support the junior investigator projects, and expedite the translation of their innovations to patient specific diagnosis and treatments of musculoskeletal diseases at the cell/molecule, tissue and body levels. The overall goal of the AFT Core is to establish the centralized resources of 3D model based designs, rapid prototyping and advanced testing for the TRIMH investigators to enable and perform their translational musculoskeletal research. The specific aims include: Aim 1 - Via the Design and Rapid prototyping role of the AFT, enable TRIMH researchers to quickly design and establish a simulated musculoskeletal component, system or environment that is a physical and biological replica of a human model to validate the virtual human trial models. Core services toward this end include mechanical design, CAD drawing, process optimization and rapid 3D printing (nano, micro and macro fabrications) of the designed parts. Aim 2 - Via the Sensor, Instrumentation and testing role of the AFT, allow the investigators to design, fabricate and install sensors onto the physical/biological replica for in situ measurement of various parameters and validation of the models. Core services to assist these outputs include sensor design, fabrication and installation, optical and electrical design, instrumentation, data acquisition, signal processing, and advanced testing/validation. Aim 3 - Promote AFT as a leading centralized, sustainable biomedical engineering resource, especially for musculoskeletal related research at Clemson University, South Carolina, and beyond. The AFT Core will be led by a multidisciplinary team consisting two engineering (mechanical and electrical) professors with the combined expertise in mechanical/optical/electrical designs, advanced manufacturing, rapid prototyping, sensors, instrumentation, imaging, and advanced testing. The COBRE fund will support experienced staff members to operate/maintain the consolidated facilities, to train/mentor TRIMH investigators to translate their innovations into clinical successes, and to facilitate the transition of the AFT Core to a competitive and self-sustained program.