San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)

项目摘要摘要 这份补充材料将支持博士生候选人Makaya Funk-White实现她的长期 目标是成为一名专注于阿尔茨海默病和阿尔茨海默病交集的独立调查员 相关痴呆症(ADRD)和药物使用。为了实现这个目标，她需要学习更多关于酒精的知识 在老年人中使用酒精，以及酒精使用在衰老过程中可能如何影响认知和大脑健康。 Makaya Funk-White女士已经确定了一个导师团队来帮助她实现这些目标，并共同努力， 他们制定了一项研究和职业发展培训活动计划，以促进实现 她的职业目标。在这本增刊中，她将与她的新导师艾米丽·里斯博士和琳达博士合作 麦克埃沃伊在一项研究项目上说，该项目正在检查神经成像测量区域皮质厚度 或体积，微结构完整性的衡量标准因饮酒量的不同而不同， 居住在社区的老年人。参与这个项目将帮助她更好地了解大脑解剖学， 神经成像技术，统计学方法，以及酒精对老年人大脑老化的影响。 她还将定期与她目前的导师艾莉森·摩尔博士会面，并参与一系列指导 这些读物加深了她对老年人物质使用的理解。这些活动将受到赞扬 通过其他研究培训活动，如研讨会、讲习班和演讲，包括参加 在圣地亚哥阿尔茨海默病少数民族老龄化研究资源中心的活动中 (ADRCMAR)和加州大学圣迭戈分校阿尔茨海默病研究中心(ADRC)。 家长助学金是加州大学圣迭戈分校和南加州大学之间的合作，旨在为 在阿尔茨海默氏症和相关痴呆症的研究中，科学家的代表性不足。方克-怀特女士是一位 代表不足的科学家，他的研究将考察酒精使用对大脑老化的影响。中等 饮酒被认为可以预防阿尔茨海默氏症的发展，但适度程度如何呢？ 饮酒对老年人大脑的影响还不是很清楚。就本研究主题而言，芬克女士-- 怀特还将学习神经解剖学和神经成像，接受统计分析和 科学写作，并将参加圣地亚哥ADRCMAR以及加州大学圣地亚哥分校的培训活动 ADRC扩大了她对阿尔茨海默氏症的了解。

Project Summary Abstract This supplement will support the candidate, PhD candidate Makaya Funk-White, to attain her long-term goal of having a career as an independent investigator focused on the intersection of Alzheimer’s disease and related dementias (ADRD) and substance use. To achieve this goal, she needs to learn more about alcohol use among older adults, and how alcohol use may affect cognitive and brain health in aging. Ms. Makaya Funk-White has identified a team of mentors to help her achieve these goals, and together, they have devised a plan of research and career development training activities that will facilitate attainment of her career goals. For this supplement, she will work with her new mentors, Drs. Emilie Reas and Linda McEvoy, on a research project that is examining whether neuroimaging measures of regional cortical thickness or volume, and measures of microstructural integrity differ by amount of alcohol drinking among healthy, community-dwelling older adults. Participating in this project will help her better understand brain anatomy, neuroimaging techniques, statistical methods, and the impact of alcohol on brain aging in older adults. She will also meet regularly with her current mentor Dr. Alison Moore and engage in a series of directed readings to further her understanding of substance use in older adults. These activities will be complimented by other research training activities such as seminars and workshops and presentations including participation in the activities of the San Diego Alzheimer’s Disease Resource Center for Minority Aging Research (ADRCMAR) and the UCSD Alzheimer’s Disease Research Center (ADRC). The parent grant is a collaboration between UCSD and SDSU to provide mentored training of underrepresented scientists in research on Alzheimer’s disease and related dementias. Ms. Funk-White is an underrepresented scientist whose research will examine the effects of alcohol use on brain aging. Moderate drinking has been suggested to protect against the development of Alzheimer’s disease, but how moderate drinking affects the brains of older adults is not well understood. In the context of this research topic, Ms. Funk- White will also learn about neuroanatomy and neuroimaging, receive training in statistical analyses and scientific writing, and will participate in training activities of the San Diego ADRCMAR as well as the UCSD ADRC to broaden her knowledge of Alzheimer’s disease.